Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation

Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation

Abstract Background MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged as a key modulator of inflammation, but its role in obesity-induced senescence remains unexplored. This study investigates the involvement of miR-146a in hig...

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Bibliographic Details
Main Authors: Keerthana Chithanathan, Monika Jürgenson, Katrina Ducena, Anu Remm, Kalev Kask, Ana Rebane, Li Tian, Alexander Zharkovsky
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Immunity & Ageing
Subjects:
High-fat diet
Hypothalamus
Microglia
Senescence
miR-146a
Elocalcitol
Online Access:https://doi.org/10.1186/s12979-024-00485-6
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