CRISPR-Cas9 editing of TNFAIP3 variants in salivary gland epithelial cells to study Sjögren’s disease pathogenesis

CRISPR-Cas9 editing of TNFAIP3 variants in salivary gland epithelial cells to study Sjögren’s disease pathogenesis

Sjögren’s disease (SD) is a systemic autoimmune disease that particularly affects the salivary and lacrimal glands, causing sicca symptoms. Genetic polymorphism in the TNFAIP3 gene has been implicated in the pathogenesis of SD. In this study, we aimed to functionally determine the impact of two spec...

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Bibliographic Details
Main Authors: Subhashis Ghosh, Qisheng Tu, Zoe Xiaofang Zhu, Sreelakshmi Panginikkod, Jake Jinkun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genome Editing
Subjects:
CRISPR-Cas9
Sjögren’s disease
TNFAIP3
NF-κB
salivary gland
single-nucleotide polymorphisms
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2025.1625393/full
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