Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight

Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight

Objectives: Dual glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor agonists (GLP1RA and GIPRA, respectively) synergise to reduce body weight. Though this synergy depends on receptors within the brain, where and how this occurs is unclear. Methods: We employed...

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Bibliographic Details
Main Authors: Claire H. Feetham, Minrong Ai, Isabella Culotta, Alessia Costa, Jenna Hunter, Robert A. Brown, Tamer Coskun, Paul J. Emmerson, Giuseppe D'Agostino, Simon M. Luckman
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Glucagon-like peptide-1
Glucose-dependent insulinotropic polypeptide
Dual-incretin agonist
Obesity
Tirzepatide
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001218
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