Valproic acid targets IDH1 mutants through alteration of lipid metabolism

Valproic acid targets IDH1 mutants through alteration of lipid metabolism

Abstract Histone deacetylases (HDACs) have a wide range of targets and can rewire both the chromatin and lipidome of cancer cells. In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhibitor, inhibits the growth of IDH1 mutant tumors i...

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Main Authors: Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-024-00021-6
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