Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study
Abstract Background This study aims to investigate the predictive significance of inflammatory markers for postoperative lung metastasis in colorectal cancer (CRC) patients. The focus is on exploring the relationship between traditional inflammatory markers, such as neutrophil-to-lymphocyte ratio (N...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12876-025-04091-8 |
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| author | Jiukang Sun Weili Xiong Zhang Fang Chuanjun Song |
| author_facet | Jiukang Sun Weili Xiong Zhang Fang Chuanjun Song |
| author_sort | Jiukang Sun |
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| description | Abstract Background This study aims to investigate the predictive significance of inflammatory markers for postoperative lung metastasis in colorectal cancer (CRC) patients. The focus is on exploring the relationship between traditional inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and newly introduced indices like C-reactive protein (CRP)–albumin–lymphocyte (CALLY), and their association with CRC progression and lung metastasis. Methods A retrospective review of medical records from 303 CRC patients at the First Affiliated Hospital of Nanjing Medical University (January 2014 to December 2023) was conducted. Various inflammatory markers, baseline characteristics, and survival data were analyzed. Statistical analyses, including univariate and multivariate Cox regression and logistic regression, were performed to determine associations between inflammatory factors and CRC outcomes. Results Among the patients, 55 developed lung metastasis during the study period. The results revealed that PNI (HR 0.368, 95% CI 0.235–0.577; p < 0.001, Table 2), LMR (HR 0.383, 95% CI 0.223–0.657; p < 0.001, Table 2), and CALLY (HR 0.18, 95% CI 0.111–0.294; p < 0.001) were associated with progression free survival (PFS). Moreover, PNI (HR 0.252, 95% CI 0.137–0.461; p < 0.001, Table 3) and CALLY (HR 0.11, 95% CI 0.0.05–0.245; p < 0.001, Table 3) emerged as independent risk factors for postoperative lung metastasis. And PNI (p = 0.028, Table 5) is more specific for predicting pulmonary metastasis in CRC. Conclusion This study underscores the importance of inflammatory markers in predicting postoperative outcomes for CRC patients. Lower PNI, LMR, and CALLY were identified as significant predictors of reduced progression free survival, while PNI and CALLY were independently associated with an increased risk of postoperative lung metastasis. Further analysis demonstrated that PNI is a specific indicator for predicting the occurrence of pulmonary metastasis in CRC, independent of metastases to other sites. These findings highlight the potential clinical utility of these inflammatory markers in monitoring CRC recurrence and metastasis. Trial registration The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (protocol code 2024—SR-066, date of approval 2024-02-27). |
| format | Article |
| id | doaj-art-ecf1f98a659840d196c86dff87f8bc52 |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-ecf1f98a659840d196c86dff87f8bc522025-08-20T04:01:41ZengBMCBMC Gastroenterology1471-230X2025-07-0125111110.1186/s12876-025-04091-8Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective studyJiukang Sun0Weili Xiong1Zhang Fang2Chuanjun Song3Department of Oncology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Oncology, The Second People’s Hospital of Lianyungang & The Oncology Hospital of LianyungangDepartment of Cardiology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Oncology, Xinghua People’s Hospital Affiliated to Yangzhou UniversityAbstract Background This study aims to investigate the predictive significance of inflammatory markers for postoperative lung metastasis in colorectal cancer (CRC) patients. The focus is on exploring the relationship between traditional inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and newly introduced indices like C-reactive protein (CRP)–albumin–lymphocyte (CALLY), and their association with CRC progression and lung metastasis. Methods A retrospective review of medical records from 303 CRC patients at the First Affiliated Hospital of Nanjing Medical University (January 2014 to December 2023) was conducted. Various inflammatory markers, baseline characteristics, and survival data were analyzed. Statistical analyses, including univariate and multivariate Cox regression and logistic regression, were performed to determine associations between inflammatory factors and CRC outcomes. Results Among the patients, 55 developed lung metastasis during the study period. The results revealed that PNI (HR 0.368, 95% CI 0.235–0.577; p < 0.001, Table 2), LMR (HR 0.383, 95% CI 0.223–0.657; p < 0.001, Table 2), and CALLY (HR 0.18, 95% CI 0.111–0.294; p < 0.001) were associated with progression free survival (PFS). Moreover, PNI (HR 0.252, 95% CI 0.137–0.461; p < 0.001, Table 3) and CALLY (HR 0.11, 95% CI 0.0.05–0.245; p < 0.001, Table 3) emerged as independent risk factors for postoperative lung metastasis. And PNI (p = 0.028, Table 5) is more specific for predicting pulmonary metastasis in CRC. Conclusion This study underscores the importance of inflammatory markers in predicting postoperative outcomes for CRC patients. Lower PNI, LMR, and CALLY were identified as significant predictors of reduced progression free survival, while PNI and CALLY were independently associated with an increased risk of postoperative lung metastasis. Further analysis demonstrated that PNI is a specific indicator for predicting the occurrence of pulmonary metastasis in CRC, independent of metastases to other sites. These findings highlight the potential clinical utility of these inflammatory markers in monitoring CRC recurrence and metastasis. Trial registration The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (protocol code 2024—SR-066, date of approval 2024-02-27).https://doi.org/10.1186/s12876-025-04091-8Colorectal cancerPrognostic valueInflammatory markersProgression-free survivalLung metastasis |
| spellingShingle | Jiukang Sun Weili Xiong Zhang Fang Chuanjun Song Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study BMC Gastroenterology Colorectal cancer Prognostic value Inflammatory markers Progression-free survival Lung metastasis |
| title | Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study |
| title_full | Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study |
| title_fullStr | Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study |
| title_full_unstemmed | Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study |
| title_short | Prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer: a retrospective study |
| title_sort | prognostic role of preoperative inflammatory markers in postoperative lung metastasis of colorectal cancer a retrospective study |
| topic | Colorectal cancer Prognostic value Inflammatory markers Progression-free survival Lung metastasis |
| url | https://doi.org/10.1186/s12876-025-04091-8 |
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