Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells
Abstract Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and my...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202416482 |
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| author | Nana Wang Yan Hou Lili Lin Shihui Xu Kyubae Lee Yingjun Yang Yazhou Chen Yachun Li Xiuhui Wang Yongtao Wang Tao Chen |
| author_facet | Nana Wang Yan Hou Lili Lin Shihui Xu Kyubae Lee Yingjun Yang Yazhou Chen Yachun Li Xiuhui Wang Yongtao Wang Tao Chen |
| author_sort | Nana Wang |
| collection | DOAJ |
| description | Abstract Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kinetics, and molecular mechanism of cytoskeleton structures to nucleate within the engineered stem cells is vague. An extensive comprehension of cell morphogenesis, force remodeling, and nuclear force‐sensing mechanotransduction is essential to reveal the basic physical principles of cytoskeleton polymerization and force‐related signaling delivery. Advanced microarrays are designed to determine heterogeneous cell morphology and cell adhesion behaviors in stem cells. The heterogeneity from the engineered microarrays is transferred into nuclei to regulate nuclear configuration and force‐sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU expression. Tuning the activation of adhesion proteins and cytoskeleton nucleators to adjust heterogeneous cell mechanics may be the underlying mechanism to change nuclear force‐sensing configuration in response to its physiological mechanotransduction in microarrayed stem cells. |
| format | Article |
| id | doaj-art-ecf182525dbe4a9cae2c61e361c4f934 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-ecf182525dbe4a9cae2c61e361c4f9342025-08-20T03:05:25ZengWileyAdvanced Science2198-38442025-04-011214n/an/a10.1002/advs.202416482Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem CellsNana Wang0Yan Hou1Lili Lin2Shihui Xu3Kyubae Lee4Yingjun Yang5Yazhou Chen6Yachun Li7Xiuhui Wang8Yongtao Wang9Tao Chen10Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 ChinaSchool of Medicine Shanghai University Shanghai 200444 ChinaDepartment of Pediatrics Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 ChinaSchool of Medicine Shanghai University Shanghai 200444 ChinaDepartment of Biomedical Materials Konyang University Daejeon 35365 Republic of KoreaMaterials Institute of Atomic and Molecular Science Shaanxi University of Science and Technology Xi'an 710021 ChinaHenan Institute of Advanced Technology Zhengzhou University Zhengzhou 450003 ChinaDepartment of Pediatrics Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 ChinaInstitute of Translational Medicine Shanghai University Shanghai 200444 ChinaSchool of Medicine Shanghai University Shanghai 200444 ChinaDepartment of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 ChinaAbstract Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells. However, further exploration of the interaction between actinin complex and myosin, kinetics, and molecular mechanism of cytoskeleton structures to nucleate within the engineered stem cells is vague. An extensive comprehension of cell morphogenesis, force remodeling, and nuclear force‐sensing mechanotransduction is essential to reveal the basic physical principles of cytoskeleton polymerization and force‐related signaling delivery. Advanced microarrays are designed to determine heterogeneous cell morphology and cell adhesion behaviors in stem cells. The heterogeneity from the engineered microarrays is transferred into nuclei to regulate nuclear configuration and force‐sensing mechanotransduction by the evaluation of Lamins, YAP, and BrdU expression. Tuning the activation of adhesion proteins and cytoskeleton nucleators to adjust heterogeneous cell mechanics may be the underlying mechanism to change nuclear force‐sensing configuration in response to its physiological mechanotransduction in microarrayed stem cells.https://doi.org/10.1002/advs.202416482advanced microarraysforce‐sensing mechanotransductionheterogeneous focal adhesionmechanical remodelingnuclear configuration |
| spellingShingle | Nana Wang Yan Hou Lili Lin Shihui Xu Kyubae Lee Yingjun Yang Yazhou Chen Yachun Li Xiuhui Wang Yongtao Wang Tao Chen Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells Advanced Science advanced microarrays force‐sensing mechanotransduction heterogeneous focal adhesion mechanical remodeling nuclear configuration |
| title | Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells |
| title_full | Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells |
| title_fullStr | Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells |
| title_full_unstemmed | Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells |
| title_short | Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells |
| title_sort | advanced microarrays as heterogeneous force remodeling coordinator to orchestrate nuclear configuration and force sensing mechanotransduction in stem cells |
| topic | advanced microarrays force‐sensing mechanotransduction heterogeneous focal adhesion mechanical remodeling nuclear configuration |
| url | https://doi.org/10.1002/advs.202416482 |
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