Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial

Objectives. This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP). Materials and Methods. This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. Al...

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Main Authors: Mahin Bakhshi, Shahzad Gholami, Arash Mahboubi, Mahmoud Reza Jaafari, Mahshid Namdari
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Dermatology Research and Practice
Online Access:http://dx.doi.org/10.1155/2020/4298193
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author Mahin Bakhshi
Shahzad Gholami
Arash Mahboubi
Mahmoud Reza Jaafari
Mahshid Namdari
author_facet Mahin Bakhshi
Shahzad Gholami
Arash Mahboubi
Mahmoud Reza Jaafari
Mahshid Namdari
author_sort Mahin Bakhshi
collection DOAJ
description Objectives. This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP). Materials and Methods. This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent t-test, repeated measures ANCOVA, Mann–Whitney test, and chi-square test. P<0.05 was considered statistically significant. Results. There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (P<0.001). The efficacy index was significantly higher in the nanocurcumin group (P<0.001). Conclusion. Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.
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spelling doaj-art-ecef3a8dbb224211bc897798791447c82025-02-03T00:59:43ZengWileyDermatology Research and Practice1687-61051687-61132020-01-01202010.1155/2020/42981934298193Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical TrialMahin Bakhshi0Shahzad Gholami1Arash Mahboubi2Mahmoud Reza Jaafari3Mahshid Namdari4Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranFood Safety Research Center, Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranObjectives. This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP). Materials and Methods. This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent t-test, repeated measures ANCOVA, Mann–Whitney test, and chi-square test. P<0.05 was considered statistically significant. Results. There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (P<0.001). The efficacy index was significantly higher in the nanocurcumin group (P<0.001). Conclusion. Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.http://dx.doi.org/10.1155/2020/4298193
spellingShingle Mahin Bakhshi
Shahzad Gholami
Arash Mahboubi
Mahmoud Reza Jaafari
Mahshid Namdari
Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
Dermatology Research and Practice
title Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
title_full Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
title_fullStr Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
title_full_unstemmed Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
title_short Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
title_sort combination therapy with 1 nanocurcumin gel and 0 1 triamcinolone acetonide mouth rinse for oral lichen planus a randomized double blind placebo controlled clinical trial
url http://dx.doi.org/10.1155/2020/4298193
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