Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
Hypertension is a major risk factor for cardiovascular disorders. As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 month...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2014/859793 |
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| author | Odile Dumont Gilles Kauffenstein Anne-Laure Guihot Nathalie C. Guérineau Pierre Abraham Laurent Loufrani Daniel Henrion |
| author_facet | Odile Dumont Gilles Kauffenstein Anne-Laure Guihot Nathalie C. Guérineau Pierre Abraham Laurent Loufrani Daniel Henrion |
| author_sort | Odile Dumont |
| collection | DOAJ |
| description | Hypertension is a major risk factor for cardiovascular disorders. As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 months. Sequential ligation of mesenteric resistance arteries allowed modifying blood flow in vivo, thus exposing arteries to low, normal, or high flow. After 1, 3, 8, or 24 weeks, arteries were isolated for in vitro study. High flow (HF) induced outward hypertrophic remodeling in WKY rats after 1 week and persisted until 24 weeks without change in wall to lumen ratio. In SHRs, diameter increase was delayed, occurring only after 3 weeks. Nevertheless, it was reduced at 8 weeks and no longer significant after 24 weeks. In parallel, media cross-section area increased more with time in SHRs than in WKY rats and this was associated with increased contractility and oxidative stress with decreased NO-dependent relaxation. Low flow induced progressive inward remodeling until 24 weeks in both strains with excessive hypertrophy in SHRs. Thus, a chronic increase in flow induced transitory diameter expansion and long-lasting hypertrophy in SHRs. This could contribute to the higher susceptibility of hypertensive subjects to ischemic diseases. |
| format | Article |
| id | doaj-art-ecea57ad06f446739561554aae381fba |
| institution | DOAJ |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-ecea57ad06f446739561554aae381fba2025-08-20T03:21:26ZengWileyInternational Journal of Hypertension2090-03842090-03922014-01-01201410.1155/2014/859793859793Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive RatsOdile Dumont0Gilles Kauffenstein1Anne-Laure Guihot2Nathalie C. Guérineau3Pierre Abraham4Laurent Loufrani5Daniel Henrion6CNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceCNRS UMR 6214, INSERM U1083, Université d’Angers, UFR de Médecine, rue Haute de Reculée, 49045 Angers, FranceHypertension is a major risk factor for cardiovascular disorders. As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 months. Sequential ligation of mesenteric resistance arteries allowed modifying blood flow in vivo, thus exposing arteries to low, normal, or high flow. After 1, 3, 8, or 24 weeks, arteries were isolated for in vitro study. High flow (HF) induced outward hypertrophic remodeling in WKY rats after 1 week and persisted until 24 weeks without change in wall to lumen ratio. In SHRs, diameter increase was delayed, occurring only after 3 weeks. Nevertheless, it was reduced at 8 weeks and no longer significant after 24 weeks. In parallel, media cross-section area increased more with time in SHRs than in WKY rats and this was associated with increased contractility and oxidative stress with decreased NO-dependent relaxation. Low flow induced progressive inward remodeling until 24 weeks in both strains with excessive hypertrophy in SHRs. Thus, a chronic increase in flow induced transitory diameter expansion and long-lasting hypertrophy in SHRs. This could contribute to the higher susceptibility of hypertensive subjects to ischemic diseases.http://dx.doi.org/10.1155/2014/859793 |
| spellingShingle | Odile Dumont Gilles Kauffenstein Anne-Laure Guihot Nathalie C. Guérineau Pierre Abraham Laurent Loufrani Daniel Henrion Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats International Journal of Hypertension |
| title | Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats |
| title_full | Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats |
| title_fullStr | Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats |
| title_full_unstemmed | Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats |
| title_short | Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats |
| title_sort | time related alteration in flow shear stress mediated remodeling in resistance arteries from spontaneously hypertensive rats |
| url | http://dx.doi.org/10.1155/2014/859793 |
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