SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis

SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis

ABSTRACT Phagocytosis of Mycobacterium tuberculosis (Mtb) followed by its integration into the matured lysosome is critical in the host defense against tuberculosis. How Mtb escapes this immune attack remains elusive. In this study, we unveiled a novel regulatory mechanism by which SIRT7 regulates c...

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Main Authors: Fuxiang Li, Ximeng Zhang, Jinjin Xu, Yue Zhang, Guo Li, Xirui Yang, Guofang Deng, Youchao Dai, Baohua Liu, Christian Kosan, Xinchun Chen, Yi Cai
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
Subjects:
tuberculosis
macrophages
actin cytoskeleton
phagocytosis
SIRT7
RAC1
Online Access:https://journals.asm.org/doi/10.1128/mbio.00756-24
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