Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer
A 42-year-old man visited a community hospital with chief complaints of lumbago and dyschesia. Computed tomography (CT) showed multiple lung, lymph node, and bone metastases and the irregular enlarged prostate with urinary bladder invasion. Serum prostate-specific antigen (PSA) was 544.0 ng/mL. Hist...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2020/5627548 |
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| _version_ | 1850163893808136192 |
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| author | Takuya Koie Yasuhiro Hashimoto Yuichiro Suzuki Yoshiomi Hatayama Futoshi Kimura |
| author_facet | Takuya Koie Yasuhiro Hashimoto Yuichiro Suzuki Yoshiomi Hatayama Futoshi Kimura |
| author_sort | Takuya Koie |
| collection | DOAJ |
| description | A 42-year-old man visited a community hospital with chief complaints of lumbago and dyschesia. Computed tomography (CT) showed multiple lung, lymph node, and bone metastases and the irregular enlarged prostate with urinary bladder invasion. Serum prostate-specific antigen (PSA) was 544.0 ng/mL. Histological evaluation showed adenocarcinoma with the Gleason score 5+4, and the clinical stage was T4N1M1c as an initial diagnosis. Although androgen deprivation therapy was performed immediately, he had castration-resistant PCa after 3 months. Therefore, he received 6 courses of docetaxel chemotherapy every 3 weeks. Serum PSA was decreased to 0.2 ng/mL, and multiple metastases and prostate size were obviously reduced based on CT. He underwent robot-assisted radical prostatectomy and radiation therapy for prostatic fossa and multiple metastases. Although serum PSA level remained low, CT showed multiple liver metastases after 3 years from surgery. He received the combination therapy of cisplatin and etoposide (PE) every 4 weeks. Liver metastases had complete response. However, he visited our hospital with complaint of vomiting and a right drooping eyelid after 6 weeks from withdrawal of PE therapy. T2-weighted magnetic resonance imaging revealed multiple leptomeningeal metastases (LM). He received RT for the brain and was administered amrubicin. However, he died of PCa after 6 weeks from the diagnosis of LM. |
| format | Article |
| id | doaj-art-ecdfd6e99fd045d4b13ce05037c0d125 |
| institution | OA Journals |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-ecdfd6e99fd045d4b13ce05037c0d1252025-08-20T02:22:06ZengWileyCase Reports in Urology2090-696X2090-69782020-01-01202010.1155/2020/56275485627548Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate CancerTakuya Koie0Yasuhiro Hashimoto1Yuichiro Suzuki2Yoshiomi Hatayama3Futoshi Kimura4Department of Urology, Gifu University Graduate School of Medicine, Gifu, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Aomori, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Aomori, JapanDepartment of Radiation Oncology, Hirosaki University Graduate School of Medicine, Aomori, JapanDepartment of Anesthesiology, Hirosaki University Graduate School of Medicine, Aomori, JapanA 42-year-old man visited a community hospital with chief complaints of lumbago and dyschesia. Computed tomography (CT) showed multiple lung, lymph node, and bone metastases and the irregular enlarged prostate with urinary bladder invasion. Serum prostate-specific antigen (PSA) was 544.0 ng/mL. Histological evaluation showed adenocarcinoma with the Gleason score 5+4, and the clinical stage was T4N1M1c as an initial diagnosis. Although androgen deprivation therapy was performed immediately, he had castration-resistant PCa after 3 months. Therefore, he received 6 courses of docetaxel chemotherapy every 3 weeks. Serum PSA was decreased to 0.2 ng/mL, and multiple metastases and prostate size were obviously reduced based on CT. He underwent robot-assisted radical prostatectomy and radiation therapy for prostatic fossa and multiple metastases. Although serum PSA level remained low, CT showed multiple liver metastases after 3 years from surgery. He received the combination therapy of cisplatin and etoposide (PE) every 4 weeks. Liver metastases had complete response. However, he visited our hospital with complaint of vomiting and a right drooping eyelid after 6 weeks from withdrawal of PE therapy. T2-weighted magnetic resonance imaging revealed multiple leptomeningeal metastases (LM). He received RT for the brain and was administered amrubicin. However, he died of PCa after 6 weeks from the diagnosis of LM.http://dx.doi.org/10.1155/2020/5627548 |
| spellingShingle | Takuya Koie Yasuhiro Hashimoto Yuichiro Suzuki Yoshiomi Hatayama Futoshi Kimura Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer Case Reports in Urology |
| title | Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer |
| title_full | Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer |
| title_fullStr | Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer |
| title_full_unstemmed | Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer |
| title_short | Leptomeningeal Metastases in a Patient with Castration-Resistant Prostate Cancer |
| title_sort | leptomeningeal metastases in a patient with castration resistant prostate cancer |
| url | http://dx.doi.org/10.1155/2020/5627548 |
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