Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions
Abstract Objectives This study aimed to extract endoscopic findings for diagnosing colorectal neoplasia associated with sessile serrated lesions (SSLs), which are of significant interest. Methods To compare the magnifying narrow‐band imaging (NBI) findings with microscopic morphology, we classified...
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Wiley
2024-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.315 |
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| author | Yuri Enomoto Mitsuaki Ishioka Akiko Chino Hikari Kobayashi Ryo Shimizu Chihiro Yasue Daisuke Ide Masahiro Igarashi Junko Fujisaki Takahisa Matsuda Yoshinori Igarashi Shoichi Saito |
| author_facet | Yuri Enomoto Mitsuaki Ishioka Akiko Chino Hikari Kobayashi Ryo Shimizu Chihiro Yasue Daisuke Ide Masahiro Igarashi Junko Fujisaki Takahisa Matsuda Yoshinori Igarashi Shoichi Saito |
| author_sort | Yuri Enomoto |
| collection | DOAJ |
| description | Abstract Objectives This study aimed to extract endoscopic findings for diagnosing colorectal neoplasia associated with sessile serrated lesions (SSLs), which are of significant interest. Methods To compare the magnifying narrow‐band imaging (NBI) findings with microscopic morphology, we classified SSLs into two groups: Group A SSLs included the majority of uniform SSLs and any dysplasia other than that classified as group B SSLs. Group B SSLs included SSLs with intramucosal and invasive carcinoma. We also quantitatively assessed visible vessels using ImageJ software. Results This study included 47 patients with 50 group B SSLs who underwent endoscopic resection between 2012 and 2020. The results were retrospectively compared with those of 237 patients with 311 group A SSLs that underwent endoscopic resection. Using conventional white‐light endoscopy, significantly more group B SSLs had uneven shapes and some reddening compared to group A SSLs. The diagnostic odds ratios for group B SSLs were as follows: lesions with a diameter ≥10 mm, 9.76; uneven shape, 3.79; reddening, 15.46; and visible vessels with NBI, 11.32. Regarding visible vessels with NBI, the specificity and diagnostic accuracy for group B SSLs were 94.9% and 93.1%, respectively. The percentage of the vascular tonal area of NBI images was significantly larger for group B SSLs than for group A SSLs (3.97% vs. 0.29%; p < 0.01). Conclusions SSLs with reddening and/or a diameter ≥10 mm are suspected to contain cancerous components. Moreover, visible vessels observed using magnifying NBI can serve as objective indicators for diagnosing SSLs with cancerous components with a high degree of accuracy. |
| format | Article |
| id | doaj-art-ecddb3e6eee149bfb2e71c7552b164c1 |
| institution | Kabale University |
| issn | 2692-4609 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-ecddb3e6eee149bfb2e71c7552b164c12025-08-20T03:38:54ZengWileyDEN Open2692-46092024-04-0141n/an/a10.1002/deo2.315Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesionsYuri Enomoto0Mitsuaki Ishioka1Akiko Chino2Hikari Kobayashi3Ryo Shimizu4Chihiro Yasue5Daisuke Ide6Masahiro Igarashi7Junko Fujisaki8Takahisa Matsuda9Yoshinori Igarashi10Shoichi Saito11Department of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanDepartment of Internal Medicine Division of Gastroenterology and Hepatology Toho University Omori Medical Center Tokyo JapanDepartment of Internal Medicine Division of Gastroenterology and Hepatology Toho University Omori Medical Center Tokyo JapanDepartment of Gastroenterology Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo JapanAbstract Objectives This study aimed to extract endoscopic findings for diagnosing colorectal neoplasia associated with sessile serrated lesions (SSLs), which are of significant interest. Methods To compare the magnifying narrow‐band imaging (NBI) findings with microscopic morphology, we classified SSLs into two groups: Group A SSLs included the majority of uniform SSLs and any dysplasia other than that classified as group B SSLs. Group B SSLs included SSLs with intramucosal and invasive carcinoma. We also quantitatively assessed visible vessels using ImageJ software. Results This study included 47 patients with 50 group B SSLs who underwent endoscopic resection between 2012 and 2020. The results were retrospectively compared with those of 237 patients with 311 group A SSLs that underwent endoscopic resection. Using conventional white‐light endoscopy, significantly more group B SSLs had uneven shapes and some reddening compared to group A SSLs. The diagnostic odds ratios for group B SSLs were as follows: lesions with a diameter ≥10 mm, 9.76; uneven shape, 3.79; reddening, 15.46; and visible vessels with NBI, 11.32. Regarding visible vessels with NBI, the specificity and diagnostic accuracy for group B SSLs were 94.9% and 93.1%, respectively. The percentage of the vascular tonal area of NBI images was significantly larger for group B SSLs than for group A SSLs (3.97% vs. 0.29%; p < 0.01). Conclusions SSLs with reddening and/or a diameter ≥10 mm are suspected to contain cancerous components. Moreover, visible vessels observed using magnifying NBI can serve as objective indicators for diagnosing SSLs with cancerous components with a high degree of accuracy.https://doi.org/10.1002/deo2.315colorectal cancernarrow‐band imagingsessile serrated adenoma/polypsessile serrated lesion with dysplasiasessile serrated lesion |
| spellingShingle | Yuri Enomoto Mitsuaki Ishioka Akiko Chino Hikari Kobayashi Ryo Shimizu Chihiro Yasue Daisuke Ide Masahiro Igarashi Junko Fujisaki Takahisa Matsuda Yoshinori Igarashi Shoichi Saito Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions DEN Open colorectal cancer narrow‐band imaging sessile serrated adenoma/polyp sessile serrated lesion with dysplasia sessile serrated lesion |
| title | Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| title_full | Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| title_fullStr | Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| title_full_unstemmed | Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| title_short | Advantage of magnifying narrow‐band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| title_sort | advantage of magnifying narrow band imaging for the diagnosis of colorectal neoplasia associated with sessile serrated lesions |
| topic | colorectal cancer narrow‐band imaging sessile serrated adenoma/polyp sessile serrated lesion with dysplasia sessile serrated lesion |
| url | https://doi.org/10.1002/deo2.315 |
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