Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery
As a natural preservative, nisin is widely used in the food industry, while its application in biomedicine is limited due to its susceptibility to interference from external conditions. In this study, a nanoparticle–hydrogel composite system was designed to encapsulate and release nisin. Nisin nanop...
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MDPI AG
2024-09-01
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| Series: | Marine Drugs |
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| author | Yueying Huang Shuting Hao Jiayu Chen Mengyuan Wang Ziheng Lin Yanan Liu |
| author_facet | Yueying Huang Shuting Hao Jiayu Chen Mengyuan Wang Ziheng Lin Yanan Liu |
| author_sort | Yueying Huang |
| collection | DOAJ |
| description | As a natural preservative, nisin is widely used in the food industry, while its application in biomedicine is limited due to its susceptibility to interference from external conditions. In this study, a nanoparticle–hydrogel composite system was designed to encapsulate and release nisin. Nisin nanoparticles were identified with a smooth, spherical visual morphology, particle size of 122.72 ± 4.88 nm, polydispersity coefficient of 0.473 ± 0.063, and zeta potential of 23.89 ± 0.37 mV. Based on the sample state and critical properties, three temperature-sensitive hydrogels based on chitosan were ultimately chosen with a rapid gelation time of 112 s, outstanding reticular structure, and optimal swelling ratio of 239.05 ± 7.15%. The composite system exhibited the same antibacterial properties as nisin, demonstrated by the composite system’s inhibition zone diameter of 17.06 ± 0.83 mm, compared to 20.20 ± 0.58 mm for nisin, which was attributed to the prolonged release effect of the hydrogel at the appropriate temperature. The composite system also demonstrated good biocompatibility and safety, making it suitable for application as short-term wound dressings in biomedicine due to its low hemolysis rate of less than 2%. In summary, our nanoparticle-based hydrogel composite system offers a novel application form of nisin while ensuring its stability, thereby deepening and broadening the employment of nisin. |
| format | Article |
| id | doaj-art-ecd2b85ecd64481ea8d809cb0b40a67b |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Marine Drugs |
| spelling | doaj-art-ecd2b85ecd64481ea8d809cb0b40a67b2025-08-20T01:55:38ZengMDPI AGMarine Drugs1660-33972024-09-0122942810.3390/md22090428Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug DeliveryYueying Huang0Shuting Hao1Jiayu Chen2Mengyuan Wang3Ziheng Lin4Yanan Liu5Department of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315800, ChinaAs a natural preservative, nisin is widely used in the food industry, while its application in biomedicine is limited due to its susceptibility to interference from external conditions. In this study, a nanoparticle–hydrogel composite system was designed to encapsulate and release nisin. Nisin nanoparticles were identified with a smooth, spherical visual morphology, particle size of 122.72 ± 4.88 nm, polydispersity coefficient of 0.473 ± 0.063, and zeta potential of 23.89 ± 0.37 mV. Based on the sample state and critical properties, three temperature-sensitive hydrogels based on chitosan were ultimately chosen with a rapid gelation time of 112 s, outstanding reticular structure, and optimal swelling ratio of 239.05 ± 7.15%. The composite system exhibited the same antibacterial properties as nisin, demonstrated by the composite system’s inhibition zone diameter of 17.06 ± 0.83 mm, compared to 20.20 ± 0.58 mm for nisin, which was attributed to the prolonged release effect of the hydrogel at the appropriate temperature. The composite system also demonstrated good biocompatibility and safety, making it suitable for application as short-term wound dressings in biomedicine due to its low hemolysis rate of less than 2%. In summary, our nanoparticle-based hydrogel composite system offers a novel application form of nisin while ensuring its stability, thereby deepening and broadening the employment of nisin.https://www.mdpi.com/1660-3397/22/9/428nisinnanoparticlesthermo-sensitive hydrogelscomposite drug delivery systembacteriostasis |
| spellingShingle | Yueying Huang Shuting Hao Jiayu Chen Mengyuan Wang Ziheng Lin Yanan Liu Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery Marine Drugs nisin nanoparticles thermo-sensitive hydrogels composite drug delivery system bacteriostasis |
| title | Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery |
| title_full | Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery |
| title_fullStr | Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery |
| title_full_unstemmed | Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery |
| title_short | Synthesis and Characterization of a Novel Chitosan-Based Nanoparticle–Hydrogel Composite System Promising for Skin Wound Drug Delivery |
| title_sort | synthesis and characterization of a novel chitosan based nanoparticle hydrogel composite system promising for skin wound drug delivery |
| topic | nisin nanoparticles thermo-sensitive hydrogels composite drug delivery system bacteriostasis |
| url | https://www.mdpi.com/1660-3397/22/9/428 |
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