Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis
Neurofibromatosis type 1 is an autosomal dominant condition which can manifest as multiple neurofibromas within subcutaneous tissue. Neurofibromas of the breast are rare and most often encountered on the nipple-areolar complexes. A 33-year-old woman presented with large, bilateral, fleshy, skin tags...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/6702561 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690057266429952 |
|---|---|
| author | Emily Hero Martyn Carey Isabelle Hero Abeer M. Shaaban |
| author_facet | Emily Hero Martyn Carey Isabelle Hero Abeer M. Shaaban |
| author_sort | Emily Hero |
| collection | DOAJ |
| description | Neurofibromatosis type 1 is an autosomal dominant condition which can manifest as multiple neurofibromas within subcutaneous tissue. Neurofibromas of the breast are rare and most often encountered on the nipple-areolar complexes. A 33-year-old woman presented with large, bilateral, fleshy, skin tags of the nipple-areolar complexes. She underwent bilateral diagnostic excision of the lesions and macroscopically, both nipple specimens displaying polypoid lesions. Histological examination showed bilateral neurofibromas comprising skin with underlying dermal proliferation of bland spindle shaped cells with wavy nuclei. Immunohistochemistry confirmed the spindle cell proliferation to be neural in origin; positive for S100 and neurofilament and negative for cytokeratins. This was associated with florid smooth muscle proliferation. This case demonstrates a rare presentation of nipple-areolar neurofibroma occurring within the skin and nipple parenchyma. Our report considers the differential diagnoses of spindle cell proliferation within the dermis and subcutis of the breast and also other deeper breast spindle cell lesions that may involve the nipple. It aims to provide an approach to diagnosing these lesions examining the literature surrounding breast neurofibromas. |
| format | Article |
| id | doaj-art-ecccf473aee04200b3e79b08a1115264 |
| institution | DOAJ |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-ecccf473aee04200b3e79b08a11152642025-08-20T03:21:26ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/67025616702561Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to DiagnosisEmily Hero0Martyn Carey1Isabelle Hero2Abeer M. Shaaban3University Hospitals Coventry and Warwickshire NHS Trust, UKDepartment of Cellular Pathology, Queen Elizabeth Hospital Birmingham, UKDepartment of Cellular Pathology, Queen Elizabeth Hospital Birmingham, UKDepartment of Cellular Pathology, Queen Elizabeth Hospital Birmingham, UKNeurofibromatosis type 1 is an autosomal dominant condition which can manifest as multiple neurofibromas within subcutaneous tissue. Neurofibromas of the breast are rare and most often encountered on the nipple-areolar complexes. A 33-year-old woman presented with large, bilateral, fleshy, skin tags of the nipple-areolar complexes. She underwent bilateral diagnostic excision of the lesions and macroscopically, both nipple specimens displaying polypoid lesions. Histological examination showed bilateral neurofibromas comprising skin with underlying dermal proliferation of bland spindle shaped cells with wavy nuclei. Immunohistochemistry confirmed the spindle cell proliferation to be neural in origin; positive for S100 and neurofilament and negative for cytokeratins. This was associated with florid smooth muscle proliferation. This case demonstrates a rare presentation of nipple-areolar neurofibroma occurring within the skin and nipple parenchyma. Our report considers the differential diagnoses of spindle cell proliferation within the dermis and subcutis of the breast and also other deeper breast spindle cell lesions that may involve the nipple. It aims to provide an approach to diagnosing these lesions examining the literature surrounding breast neurofibromas.http://dx.doi.org/10.1155/2018/6702561 |
| spellingShingle | Emily Hero Martyn Carey Isabelle Hero Abeer M. Shaaban Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis Case Reports in Pathology |
| title | Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis |
| title_full | Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis |
| title_fullStr | Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis |
| title_full_unstemmed | Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis |
| title_short | Bilateral Neurofibromas of the Nipple-Areolar Complex: A Case Report and Approach to Diagnosis |
| title_sort | bilateral neurofibromas of the nipple areolar complex a case report and approach to diagnosis |
| url | http://dx.doi.org/10.1155/2018/6702561 |
| work_keys_str_mv | AT emilyhero bilateralneurofibromasofthenippleareolarcomplexacasereportandapproachtodiagnosis AT martyncarey bilateralneurofibromasofthenippleareolarcomplexacasereportandapproachtodiagnosis AT isabellehero bilateralneurofibromasofthenippleareolarcomplexacasereportandapproachtodiagnosis AT abeermshaaban bilateralneurofibromasofthenippleareolarcomplexacasereportandapproachtodiagnosis |