A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke
Background: Stroke is one of the major causes of morbidity and mortality worldwide. Various studies have examined the neuroprotective effects of magnesium and potassium ions through their effects on the glutamate receptor and the endothelium, achieved by lowering blood pressure and through their ant...
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Golestan University of Medical Sciences
2024-07-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1750-en.pdf |
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| author | Sudhanshu Subrat Manohar Lal Prasad Kavya Varshney Kanika Bansal Mayank Mahajan Anindya Chowdhury |
| author_facet | Sudhanshu Subrat Manohar Lal Prasad Kavya Varshney Kanika Bansal Mayank Mahajan Anindya Chowdhury |
| author_sort | Sudhanshu Subrat |
| collection | DOAJ |
| description | Background: Stroke is one of the major causes of morbidity and mortality worldwide. Various studies have examined the neuroprotective effects of magnesium and potassium ions through their effects on the glutamate receptor and the endothelium, achieved by lowering blood pressure and through their anti-inflammatory and anti-apoptotic properties. The objective of our study was to determine the prognostic significance of serum magnesium and serum potassium levels in acute stroke.
Methods: An observational study was conducted at Rajendra Institute of Medical Sciences, Ranchi, for 18 months on 150 adults in patients with acute stroke, enrolled within 72 hours after applying appropriate inclusion and exclusion criteria. Correlations between the Modified Rankin Scale (mRS) score at discharge and the Glasgow Coma Scale (GCS) score at admission with serum levels of magnesium and potassium were calculated. Statistical analysis was performed using SPSS software version 27.0.
Results: Two groups were formed based on serum magnesium levels: <1.5 mg/dL and >1.5 mg/dL. Similarly, two groups were created based on serum potassium levels: <3.5 mEq/L and >3.5 mEq/L. A significant correlation was found, using Spearman’s coefficient test, between serum potassium and magnesium levels and the GCS score at admission, as well as the mRS score at discharge (p < 0.05).
Conclusion: Lower concentrations of magnesium and potassium are associated with increased cerebral arterial contraction and greater neurological damage. |
| format | Article |
| id | doaj-art-eccafe5555734076a7d9a34e0a80a49f |
| institution | DOAJ |
| issn | 2538-4449 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj-art-eccafe5555734076a7d9a34e0a80a49f2025-08-20T03:08:06ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492024-07-011841416A study of prognostic significance of serum magnesium and serum potassium levels in acute strokeSudhanshu Subrat0Manohar Lal Prasad1Kavya Varshney2Kanika Bansal3Mayank Mahajan4Anindya Chowdhury5 Department of Medicine, MGM Medical College, Jamshedpur, India Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, India Department of Lab Medicine, Delhi State Cancer Institute, Delhi, India Department of Paediatrics, Lala Lajpat Rai Memorial Medical College, Meerut, India Department of Medicine, Shaheed Nirmal Mahato Medical College and Hospital, Dhanbad, India Department of Medicine, MGM Medical College, Jamshedpur, India Background: Stroke is one of the major causes of morbidity and mortality worldwide. Various studies have examined the neuroprotective effects of magnesium and potassium ions through their effects on the glutamate receptor and the endothelium, achieved by lowering blood pressure and through their anti-inflammatory and anti-apoptotic properties. The objective of our study was to determine the prognostic significance of serum magnesium and serum potassium levels in acute stroke. Methods: An observational study was conducted at Rajendra Institute of Medical Sciences, Ranchi, for 18 months on 150 adults in patients with acute stroke, enrolled within 72 hours after applying appropriate inclusion and exclusion criteria. Correlations between the Modified Rankin Scale (mRS) score at discharge and the Glasgow Coma Scale (GCS) score at admission with serum levels of magnesium and potassium were calculated. Statistical analysis was performed using SPSS software version 27.0. Results: Two groups were formed based on serum magnesium levels: <1.5 mg/dL and >1.5 mg/dL. Similarly, two groups were created based on serum potassium levels: <3.5 mEq/L and >3.5 mEq/L. A significant correlation was found, using Spearman’s coefficient test, between serum potassium and magnesium levels and the GCS score at admission, as well as the mRS score at discharge (p < 0.05). Conclusion: Lower concentrations of magnesium and potassium are associated with increased cerebral arterial contraction and greater neurological damage.http://mlj.goums.ac.ir/article-1-1750-en.pdfstrokemagnesiumpotassiumglasgow coma scalemodified rankin scale |
| spellingShingle | Sudhanshu Subrat Manohar Lal Prasad Kavya Varshney Kanika Bansal Mayank Mahajan Anindya Chowdhury A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke Medical Laboratory Journal stroke magnesium potassium glasgow coma scale modified rankin scale |
| title | A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| title_full | A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| title_fullStr | A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| title_full_unstemmed | A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| title_short | A study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| title_sort | study of prognostic significance of serum magnesium and serum potassium levels in acute stroke |
| topic | stroke magnesium potassium glasgow coma scale modified rankin scale |
| url | http://mlj.goums.ac.ir/article-1-1750-en.pdf |
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