Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarrhea (ABCD) trial

Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarrhea (ABCD) trial

BackgroundMulti-pathogen molecular diagnostics enhance our understanding of the pathogen-specific burden of diarrhea. However, attributing etiology remains challenging in high-burden settings where coinfections are common. The Antibiotics for Children with severe Diarrhea (ABCD) trial provides a uni...

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Main Authors: Jennifer Cornick, Sarah Elwood, James Platts-Mills, Patricia Pavlinac, Karim Premji Manji, Christopher R. Sudfeld, Christopher P. Duggan, Queen Dube, Naor Bar-Zeev, Karen Kotloff, Samba O. Sow, Sunil Sazawal, Benson Singa, Judd L. Walson, Farah Naz Qamar, Tahmeed Ahmed, Ayesha De Costa, Elizabeth T. Rogawski McQuade
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
diarrhea
azihtromycin
etiology
children
Shigella
RT-PCR
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1606207/full
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