Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures

Abstract Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and...

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Main Authors: Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber
Format: Article
Language:English
Published: Springer Nature 2017-02-01
Series:Molecular Systems Biology
Subjects:
aneuploidy
DNA copy number alterations
genomic instability
glycolysis
metabolism
Online Access:https://doi.org/10.15252/msb.20167159
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