Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system.

Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system.

Rats and mice are essential experimental animals in preclinical research, serving as models for various human diseases and contributing significantly to drug development. Rats offer distinct advantages over mice due to their larger size, which allows for more complex surgical procedures, repeated bl...

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Bibliographic Details
Main Authors: Katsuyuki Nakamura, Sara Ito, Yoshihiro Ohguchi, Toshie Jimbo, Yusaku Wada, Ryota Nakajima, Masanobu Kanou, Kei Yamana, Hiroshi Ueda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325444
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