Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils

Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils

Abstract Despite known sex differences in human synucleinopathies such as Parkinson’s disease, the impact of sex on alpha-synuclein pathology in mouse models has been largely overlooked. To address this need, we examine sex differences in whole brain signatures of neurodegeneration due to aSyn toxic...

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Main Authors: Stephanie Tullo, Janice Sung Hyun Park, Daniel Gallino, Megan Park, Kristie Mar, Vladislav Novikov, Rodrigo Sandoval Contreras, Raihaan Patel, Esther del Cid-Pellitero, Edward A. Fon, Wen Luo, Irina Shlaifer, Thomas M. Durcan, Marco A. M. Prado, Vania F. Prado, Gabriel A. Devenyi, M. Mallar Chakravarty
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07680-1
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