The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation

The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation

IntroductionThe presentation of pathogen-derived antigens on major histocompatibility complex (MHC) class I is crucial for the antiviral immune response. Degradation of intracellular pathogen-derived proteins by the 26S proteasome generates peptides that can be loaded on MHC-I molecules and presente...

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Bibliographic Details
Main Authors: Natalie Pach, Sarah Ochs, Jinjing Cao, Julia Ottlinger, Annette Aichem, Michael Basler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
FAT10
UBD
proteasome
MHC-I
antigen processing
antigen presentation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636951/full
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