FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1

FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1

Abstract Aging is characterized by changes in gene expression, some of which can drive deleterious cellular phenotypes and senescence. The transcriptional activation of senescence genes has been mainly attributed to epigenetic shifts, but the changes in chromatin accessibility and its underlying mec...

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Bibliographic Details
Main Authors: Fábio J. Ferreira, Mafalda Galhardo, João M. Nogueira, Joana Teixeira, Elsa Logarinho, José Bessa
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57503-4
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