Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination

Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination

Abstract Targeting dendritic cells (DCs) with antigens is a promising approach to modulating T follicular helper (Tfh) cells and germinal center (GC) reactions, enhancing vaccine-induced adaptive immune responses, with preclinical studies highlighting a key role of Langerhans cells (LCs) in generati...

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Main Authors: Juliane S. Lanza, Adele Hammoudi, Joanna De Chiara, Mathieu Surenaud, Anaïs Kembou, Michela Esposito, Sandra Zurawski, Gerard Zurawski, Mireille Centlivre, Bernard Malissen, Véronique Godot, Yves Lévy, Sandrine Henri, Sylvain Cardinaud
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01214-w
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https://doi.org/10.1038/s41541-025-01214-w

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