Single-cell transcriptome profiling of m6A regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients

Single-cell transcriptome profiling of m6A regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients

Abstract Millions of people worldwide die of acute myeloid leukaemia (AML) each year. Although N6-methyladenosine (m6A) modification has been reported to regulate the pathogenicity of AML, the mechanisms by which m6A induces dysfunctional hematopoietic differentiation in elderly AML patients remain...

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Bibliographic Details
Main Authors: Zhe Wang, Xin Du, Peidong Zhang, Meiling Zhao, Tianbo Zhang, Jiang Liu, Xiaolan Wang, Doudou Chang, Xiaxia Liu, Sicheng Bian, Xialin Zhang, Ruijuan Zhang
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Molecular Biomedicine
Subjects:
M6A
Acute myeloid leukemia
Malignant differentiation
WNT signaling
Single-cell RNA-seq
Online Access:https://doi.org/10.1186/s43556-024-00234-7
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