Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney
Abstract Introduction: Patients with solitary functioning kidney (SFK) have glomerular hyperfiltration, hypertension, proteinuria and impaired renal function resulting in microvascular atherosclerotic abnormalities. This condition leads to an increase in arterial stiffness. In this study, we aimed...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Nefrologia
2025-03-01
|
| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200306&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850050011545468928 |
|---|---|
| author | Seçil Conkar Tunçay Gonca Koç Gülden Hakverdi |
| author_facet | Seçil Conkar Tunçay Gonca Koç Gülden Hakverdi |
| author_sort | Seçil Conkar Tunçay |
| collection | DOAJ |
| description | Abstract Introduction: Patients with solitary functioning kidney (SFK) have glomerular hyperfiltration, hypertension, proteinuria and impaired renal function resulting in microvascular atherosclerotic abnormalities. This condition leads to an increase in arterial stiffness. In this study, we aimed to investigate the usefulness of non-invasive renal Doppler ultrasonography hemodynamic parameters in demonstrating arterial stiffness in pediatric patients with SFK. Methods: The study included 59 children aged 6–18 years who were diagnosed with SFK. Demographic, biochemical, anthropometric, and blood pressure data were recorded. The renal Doppler ultrasound hemodynamic parameters renal resistive index (RRI), renal pulsatility index (RPI), carotid-femoral pulse wave velocity (cfPWV), central augmentation index (cAIx) and carotid intima media thickness (cIMT) were evaluated. Results: Eighteen (30.5%) cases with acquired SFK and 41 (64.5%) cases with congenital SFK were detected. Central augmentation indices were higher in children with congenital SFK than in children with acquired SFK (p = 0.038). CkiD-eGFR-SCr-CysC was lower in patients with acquired SFK (p = 0.011). LDL cholesterol levels were higher in children with acquired SFK (p = 0.018). We found a significant correlation between RPI and cfPWV with a correlation coefficient (r) of 0.321 and a statistically significant p-value of 0.013. Conclusions: Congenital SFK is associated with increased microvascular atherosclerotic burden. RPI assessment with renal Doppler ultrasound may be a non-invasive method to identify arterial stiffness. |
| format | Article |
| id | doaj-art-ecbd572d1d474280bc5ffc0694d751e8 |
| institution | DOAJ |
| issn | 2175-8239 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj-art-ecbd572d1d474280bc5ffc0694d751e82025-08-20T02:53:34ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392025-03-0147210.1590/2175-8239-jbn-2024-0069enUltrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidneySeçil Conkar Tunçayhttps://orcid.org/0000-0002-2491-9914Gonca Koçhttps://orcid.org/0000-0002-0564-5014Gülden Hakverdihttps://orcid.org/0000-0002-8078-0451Abstract Introduction: Patients with solitary functioning kidney (SFK) have glomerular hyperfiltration, hypertension, proteinuria and impaired renal function resulting in microvascular atherosclerotic abnormalities. This condition leads to an increase in arterial stiffness. In this study, we aimed to investigate the usefulness of non-invasive renal Doppler ultrasonography hemodynamic parameters in demonstrating arterial stiffness in pediatric patients with SFK. Methods: The study included 59 children aged 6–18 years who were diagnosed with SFK. Demographic, biochemical, anthropometric, and blood pressure data were recorded. The renal Doppler ultrasound hemodynamic parameters renal resistive index (RRI), renal pulsatility index (RPI), carotid-femoral pulse wave velocity (cfPWV), central augmentation index (cAIx) and carotid intima media thickness (cIMT) were evaluated. Results: Eighteen (30.5%) cases with acquired SFK and 41 (64.5%) cases with congenital SFK were detected. Central augmentation indices were higher in children with congenital SFK than in children with acquired SFK (p = 0.038). CkiD-eGFR-SCr-CysC was lower in patients with acquired SFK (p = 0.011). LDL cholesterol levels were higher in children with acquired SFK (p = 0.018). We found a significant correlation between RPI and cfPWV with a correlation coefficient (r) of 0.321 and a statistically significant p-value of 0.013. Conclusions: Congenital SFK is associated with increased microvascular atherosclerotic burden. RPI assessment with renal Doppler ultrasound may be a non-invasive method to identify arterial stiffness.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200306&tlng=enSolitary KidneyVascular StiffnessRenal Pulsatility IndexChild |
| spellingShingle | Seçil Conkar Tunçay Gonca Koç Gülden Hakverdi Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney Brazilian Journal of Nephrology Solitary Kidney Vascular Stiffness Renal Pulsatility Index Child |
| title | Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| title_full | Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| title_fullStr | Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| title_full_unstemmed | Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| title_short | Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| title_sort | ultrasound doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney |
| topic | Solitary Kidney Vascular Stiffness Renal Pulsatility Index Child |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002025000200306&tlng=en |
| work_keys_str_mv | AT secilconkartuncay ultrasounddopplerrenalpulsatilityindexisapredictivemarkerofarterialstiffnessinchildrenwithsolitaryfunctioningkidney AT goncakoc ultrasounddopplerrenalpulsatilityindexisapredictivemarkerofarterialstiffnessinchildrenwithsolitaryfunctioningkidney AT guldenhakverdi ultrasounddopplerrenalpulsatilityindexisapredictivemarkerofarterialstiffnessinchildrenwithsolitaryfunctioningkidney |