Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.

<h4>Background</h4>The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. The prediction has been that reducing Abeta production...

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Bibliographic Details
Main Authors: Joanna L Jankowsky, Hilda H Slunt, Victoria Gonzales, Alena V Savonenko, Jason C Wen, Nancy A Jenkins, Neal G Copeland, Linda H Younkin, Henry A Lester, Steven G Younkin, David R Borchelt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-12-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0020355&type=printable
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