Different <sup>212</sup>Pb Generators and Its Radiation Safety Concerning <sup>220</sup>Rn (Thoron) Emanation

Different <sup>212</sup>Pb Generators and Its Radiation Safety Concerning <sup>220</sup>Rn (Thoron) Emanation

(1) Background: As the demand for <sup>212</sup>Pb for clinical theranostics rises, empirical studies that examine the radiation safety implications of different <sup>224</sup>Ra sources are needed to facilitate discussions with local authorities for the translation of <su...

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Bibliographic Details
Main Authors: Marc Pretze, Holger Hartmann, Charlotte Duchemin, Thierry Stora, Muhammad Inzamam, David Kästner, Edwin A. Sagastume, Michael K. Schultz, Jörg Kotzerke, Ralph A. Bundschuh, Robert Freudenberg
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Toxics
Subjects:
<sup>224</sup>Ra
<sup>220</sup>Rn
<sup>212</sup>Pb
alpha detection
dosimetry
radiation safety
Online Access:https://www.mdpi.com/2305-6304/13/6/462
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Summary:(1) Background: As the demand for <sup>212</sup>Pb for clinical theranostics rises, empirical studies that examine the radiation safety implications of different <sup>224</sup>Ra sources are needed to facilitate discussions with local authorities for the translation of <sup>203/212</sup>Pb theranostics routine clinical practice. (2) Methods: Environmental <sup>220</sup>Rn (Thoron) emanation was detected by a RAD7 detector in the vicinity of respective <sup>212</sup>Pb sources and additional alpha-dosimeters to detect <sup>220</sup>Rn during generator elution, radiosynthesis, and quality control. Personnel gamma exposure was measured using whole-body and ring dosimeters. Generators included those based on wet-chemical-process- and emanation-based technology. (3) Results: During generator handling, varying levels of <sup>220</sup>Rn were observed in the vicinity of generators. An additional monthly whole-body dose must be considered when handling different sources of <sup>212</sup>Pb generators, and this depends upon local shielding and the handling approaches toward use of the technology. (4) Conclusions: <sup>224</sup>Ra in any form (including radionuclide generators) should always be handled within a fume hood to keep potential contamination and exposure to personnel as low as reasonably achievable. Following standard practices of radiation safety, generators of <sup>212</sup>Pb can be used safely for theranostic applications.
ISSN:2305-6304

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