A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming
An acute response of LH to a stimulatory pulse of GnRH is modelled as a result of a pathway (Pathway I) that consists of two compartments including a single (rate limiting) intermediate. In addition, a second pathway (Pathway II) was added, consisting of an intermediate transcription factor and sub...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/410348 |
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| author | J. J. Evans T. M. Wilkinson D. J. N. Wall |
| author_facet | J. J. Evans T. M. Wilkinson D. J. N. Wall |
| author_sort | J. J. Evans |
| collection | DOAJ |
| description | An acute response of LH to a stimulatory pulse of
GnRH is modelled as a result of a pathway (Pathway I) that
consists of two compartments including a single (rate limiting)
intermediate. In addition, a second pathway (Pathway II) was
added, consisting of an intermediate transcription factor and
subsequently a synthesised protein. Pathway II had a delayed
effect on LH release due to the time taken to produce the
intermediate protein. The model included synergism between
these two pathways, which yielded an augmented response.
The model accounts for a number of observations, including
GnRH self-priming and the biphasic pattern of LH response.
The same model was used to fit the data of the LH response
when gonadotrophs responded to the addition of oxytocin in the
response with a shoulder on the profile. Pathway I is able to be
conceptualised as the basic Ca2+-mediated pathway. Pathway II
contains features characteristic of the cAMP-mediated pathway.
Thus, we have provided an explanation for details of the nature of
the profile of LH secretion and additionally enabled incorporation
of cAMP in an integrating model. The study investigated the
possibility of two interacting pathways being at the basis of both
the shoulder on the LH surges and self-priming, and the model
illustrates that this appears to be highly likely. |
| format | Article |
| id | doaj-art-ecac7b57106d4687abc7aa623f49310b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ecac7b57106d4687abc7aa623f49310b2025-02-03T05:58:59ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/410348410348A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-PrimingJ. J. Evans0T. M. Wilkinson1D. J. N. Wall2Centre for Neuroendocrinology, University of Otago, Christchurch, New ZealandDepartment of Obstetrics and Gynaecology, University of Otago, Christchurch, New ZealandBiomathematics Research Centre, University of Canterbury, Christchurch, New ZealandAn acute response of LH to a stimulatory pulse of GnRH is modelled as a result of a pathway (Pathway I) that consists of two compartments including a single (rate limiting) intermediate. In addition, a second pathway (Pathway II) was added, consisting of an intermediate transcription factor and subsequently a synthesised protein. Pathway II had a delayed effect on LH release due to the time taken to produce the intermediate protein. The model included synergism between these two pathways, which yielded an augmented response. The model accounts for a number of observations, including GnRH self-priming and the biphasic pattern of LH response. The same model was used to fit the data of the LH response when gonadotrophs responded to the addition of oxytocin in the response with a shoulder on the profile. Pathway I is able to be conceptualised as the basic Ca2+-mediated pathway. Pathway II contains features characteristic of the cAMP-mediated pathway. Thus, we have provided an explanation for details of the nature of the profile of LH secretion and additionally enabled incorporation of cAMP in an integrating model. The study investigated the possibility of two interacting pathways being at the basis of both the shoulder on the LH surges and self-priming, and the model illustrates that this appears to be highly likely.http://dx.doi.org/10.1155/2013/410348 |
| spellingShingle | J. J. Evans T. M. Wilkinson D. J. N. Wall A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming International Journal of Endocrinology |
| title | A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming |
| title_full | A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming |
| title_fullStr | A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming |
| title_full_unstemmed | A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming |
| title_short | A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming |
| title_sort | two pathway mathematical model of the lh response to gnrh that predicts self priming |
| url | http://dx.doi.org/10.1155/2013/410348 |
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