Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers
The Eph (erythropoietin-producing hepatocellular carcinoma) receptor family represents the largest subgroup within the tyrosine kinase receptor family and is recognized for its critical role in regulating the growth, migration, and survival of both normal and malignant cells. The Eph/ephrin signalin...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1554751/full |
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| author | Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Luccas Lavareze Luccas Lavareze João Figueira Scarini João Figueira Scarini Talita de Carvalho Kimura Talita de Carvalho Kimura Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal |
| author_facet | Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Luccas Lavareze Luccas Lavareze João Figueira Scarini João Figueira Scarini Talita de Carvalho Kimura Talita de Carvalho Kimura Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal |
| author_sort | Reydson Alcides de Lima-Souza |
| collection | DOAJ |
| description | The Eph (erythropoietin-producing hepatocellular carcinoma) receptor family represents the largest subgroup within the tyrosine kinase receptor family and is recognized for its critical role in regulating the growth, migration, and survival of both normal and malignant cells. The Eph/ephrin signaling has an ambiguous role in squamous cell carcinomas of the oral region, playing both a suppressive and oncogenic role. In salivary gland cancers, the results are reserved, although they suggest that some molecules are associated with a worse prognosis for patients. This review offers a comprehensive summary of the existing literature, underscoring the evidence that supports the involvement of the Eph/ephrin signaling in oral and maxillofacial cancers. Additionally, we examine molecular discoveries that may present promising therapeutic targets for these malignancies. |
| format | Article |
| id | doaj-art-eca427522e604773adce3d27bdaa917c |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-eca427522e604773adce3d27bdaa917c2025-08-20T03:09:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15547511554751Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancersReydson Alcides de Lima-Souza0Reydson Alcides de Lima-Souza1Moisés Willian Aparecido Gonçalves2Moisés Willian Aparecido Gonçalves3Raisa Sales de Sá4Luccas Lavareze5Luccas Lavareze6João Figueira Scarini7João Figueira Scarini8Talita de Carvalho Kimura9Talita de Carvalho Kimura10Fernanda Cristina Poscai Ribeiro11Albina Altemani12Fernanda Viviane Mariano13Gary Chris Fillmore14Erika Said Abu Egal15Erika Said Abu Egal16Department of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Oral Diagnosis, Piracicaba School of Dentistry, University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, BrazilDepartment of Internal Medicine, University of Western São Paulo (UNOESTE), Guarujá, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilBiorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United StatesDepartment of Pathology, School of Medical Sciences, University of Campinas (FCM/UNICAMP), Campinas, São Paulo, BrazilBiorepository and Molecular Pathology, Huntsman Cancer Institute, University of Utah (UU), Salt Lake City, UT, United StatesThe Eph (erythropoietin-producing hepatocellular carcinoma) receptor family represents the largest subgroup within the tyrosine kinase receptor family and is recognized for its critical role in regulating the growth, migration, and survival of both normal and malignant cells. The Eph/ephrin signaling has an ambiguous role in squamous cell carcinomas of the oral region, playing both a suppressive and oncogenic role. In salivary gland cancers, the results are reserved, although they suggest that some molecules are associated with a worse prognosis for patients. This review offers a comprehensive summary of the existing literature, underscoring the evidence that supports the involvement of the Eph/ephrin signaling in oral and maxillofacial cancers. Additionally, we examine molecular discoveries that may present promising therapeutic targets for these malignancies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1554751/fullEphephrinoral squamous cell carcinomasalivary gland cancerstarget therapy |
| spellingShingle | Reydson Alcides de Lima-Souza Reydson Alcides de Lima-Souza Moisés Willian Aparecido Gonçalves Moisés Willian Aparecido Gonçalves Raisa Sales de Sá Luccas Lavareze Luccas Lavareze João Figueira Scarini João Figueira Scarini Talita de Carvalho Kimura Talita de Carvalho Kimura Fernanda Cristina Poscai Ribeiro Albina Altemani Fernanda Viviane Mariano Gary Chris Fillmore Erika Said Abu Egal Erika Said Abu Egal Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers Frontiers in Oncology Eph ephrin oral squamous cell carcinoma salivary gland cancers target therapy |
| title | Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers |
| title_full | Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers |
| title_fullStr | Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers |
| title_full_unstemmed | Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers |
| title_short | Exploring the complex role of the Eph/Ephrin signaling in oral and maxillofacial cancers |
| title_sort | exploring the complex role of the eph ephrin signaling in oral and maxillofacial cancers |
| topic | Eph ephrin oral squamous cell carcinoma salivary gland cancers target therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1554751/full |
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