Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study
Abstract Severe traumatic brain injury (sTBI) is a significant public health concern with high disability and mortality rates. No reliable diagnostic tools exist to determine surgical indications or predict prognosis. To assess the clinical value of computed tomography angiography (CTA) and perfusio...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99241-z |
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| author | Tiantian Liu Wenxia Qian Yan Jiang Ying Yang Yanping Ding |
| author_facet | Tiantian Liu Wenxia Qian Yan Jiang Ying Yang Yanping Ding |
| author_sort | Tiantian Liu |
| collection | DOAJ |
| description | Abstract Severe traumatic brain injury (sTBI) is a significant public health concern with high disability and mortality rates. No reliable diagnostic tools exist to determine surgical indications or predict prognosis. To assess the clinical value of computed tomography angiography (CTA) and perfusion (CTP) in sTBI, and compare treatment efficacy based on traditional imaging versus CTA/CTP assessment. This retrospective study included 169 patients with sTBI who underwent CTA/CTP at admission and postoperatively to guide treatment decisions. Another 132 patients received treatment based on traditional imaging. Clinical outcomes and complications were compared between the two groups. Baseline characteristics did not differ significantly between groups. Although the 6-month Glasgow outcome scale (GOS) scores were comparable, in-hospital mortality was lower in the CTA/CTP group, and the craniotomy rate was significantly reduced. A higher proportion of patients who underwent the operation in the CTA/CTP group had favorable prognoses. Moreover, the hospitalization duration and costs were substantially lower in the CTA/CTP group. The CTA/CTP imaging provides critical cerebrovascular and perfusion data in sTBI, aiding in surgical decision-making and perioperative management. |
| format | Article |
| id | doaj-art-ec975d69fe0147a2aea573c792a60b15 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ec975d69fe0147a2aea573c792a60b152025-08-20T02:20:01ZengNature PortfolioScientific Reports2045-23222025-04-011511710.1038/s41598-025-99241-zClinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective studyTiantian Liu0Wenxia Qian1Yan Jiang2Ying Yang3Yanping Ding4Department of Imaging, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityDepartment of Imaging, Kunshan Traditional Chinese Medicine HospitalDepartment of Imaging, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityDepartment of Imaging, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityDepartment of Imaging, Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityAbstract Severe traumatic brain injury (sTBI) is a significant public health concern with high disability and mortality rates. No reliable diagnostic tools exist to determine surgical indications or predict prognosis. To assess the clinical value of computed tomography angiography (CTA) and perfusion (CTP) in sTBI, and compare treatment efficacy based on traditional imaging versus CTA/CTP assessment. This retrospective study included 169 patients with sTBI who underwent CTA/CTP at admission and postoperatively to guide treatment decisions. Another 132 patients received treatment based on traditional imaging. Clinical outcomes and complications were compared between the two groups. Baseline characteristics did not differ significantly between groups. Although the 6-month Glasgow outcome scale (GOS) scores were comparable, in-hospital mortality was lower in the CTA/CTP group, and the craniotomy rate was significantly reduced. A higher proportion of patients who underwent the operation in the CTA/CTP group had favorable prognoses. Moreover, the hospitalization duration and costs were substantially lower in the CTA/CTP group. The CTA/CTP imaging provides critical cerebrovascular and perfusion data in sTBI, aiding in surgical decision-making and perioperative management.https://doi.org/10.1038/s41598-025-99241-zCT angiographySevere traumatic brain injuryCraniotomy |
| spellingShingle | Tiantian Liu Wenxia Qian Yan Jiang Ying Yang Yanping Ding Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study Scientific Reports CT angiography Severe traumatic brain injury Craniotomy |
| title | Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| title_full | Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| title_fullStr | Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| title_full_unstemmed | Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| title_short | Clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| title_sort | clinical study of computerized tomography angiography and computerized tomography perfusion in severe traumatic brain injury by a multicenter retrospective study |
| topic | CT angiography Severe traumatic brain injury Craniotomy |
| url | https://doi.org/10.1038/s41598-025-99241-z |
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