An Update on RNA Virus Discovery: Current Challenges and Future Perspectives
The relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens. This review provides a comprehensive update on recent advancements in RNA virus discovery, highlighting breakth...
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| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/7/983 |
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| author | Humberto Debat Nicolas Bejerman |
| author_facet | Humberto Debat Nicolas Bejerman |
| author_sort | Humberto Debat |
| collection | DOAJ |
| description | The relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens. This review provides a comprehensive update on recent advancements in RNA virus discovery, highlighting breakthroughs in technology and methodologies that have significantly enhanced our ability to identify novel viruses across diverse host organisms. We explore the expanding landscape of viral diversity, emphasizing the discovery of previously unknown viral families and the role of zoonotic transmissions in shaping the viral ecosystem. Additionally, we discuss the potential implications of RNA virus discovery on disease emergence and pandemic preparedness. Despite remarkable progress, current challenges in sample collection, data interpretation, and the characterization of newly identified viruses persist. Our ability to anticipate and respond to emerging respiratory threats relies on virus discovery as a cornerstone for understanding RNA virus evolution. We address these challenges and propose future directions for research, emphasizing the integration of multi-omic approaches, advanced computational tools, and international collaboration to overcome barriers in the field. This comprehensive overview aims to guide researchers, policymakers, and public health professionals in navigating the intricate landscape of RNA virus discovery, fostering a proactive and collaborative approach to anticipate and mitigate emerging viral threats. |
| format | Article |
| id | doaj-art-ec961b01dab9489da32a8fe32fe8764a |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-ec961b01dab9489da32a8fe32fe8764a2025-08-20T02:47:08ZengMDPI AGViruses1999-49152025-07-0117798310.3390/v17070983An Update on RNA Virus Discovery: Current Challenges and Future PerspectivesHumberto Debat0Nicolas Bejerman1Instituto de Patología Vegetal, Centro de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria (IPAVE-CIAP-INTA), Unidad de Fitopatología y Modelización Agrícola CONICET-INTA, Córdoba 5020, ArgentinaInstituto de Patología Vegetal, Centro de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria (IPAVE-CIAP-INTA), Unidad de Fitopatología y Modelización Agrícola CONICET-INTA, Córdoba 5020, ArgentinaThe relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens. This review provides a comprehensive update on recent advancements in RNA virus discovery, highlighting breakthroughs in technology and methodologies that have significantly enhanced our ability to identify novel viruses across diverse host organisms. We explore the expanding landscape of viral diversity, emphasizing the discovery of previously unknown viral families and the role of zoonotic transmissions in shaping the viral ecosystem. Additionally, we discuss the potential implications of RNA virus discovery on disease emergence and pandemic preparedness. Despite remarkable progress, current challenges in sample collection, data interpretation, and the characterization of newly identified viruses persist. Our ability to anticipate and respond to emerging respiratory threats relies on virus discovery as a cornerstone for understanding RNA virus evolution. We address these challenges and propose future directions for research, emphasizing the integration of multi-omic approaches, advanced computational tools, and international collaboration to overcome barriers in the field. This comprehensive overview aims to guide researchers, policymakers, and public health professionals in navigating the intricate landscape of RNA virus discovery, fostering a proactive and collaborative approach to anticipate and mitigate emerging viral threats.https://www.mdpi.com/1999-4915/17/7/983RNA virus discoveryviral evolutionmetagenomicszoonotic spillovervirus surveillanceemerging respiratory viruses |
| spellingShingle | Humberto Debat Nicolas Bejerman An Update on RNA Virus Discovery: Current Challenges and Future Perspectives Viruses RNA virus discovery viral evolution metagenomics zoonotic spillover virus surveillance emerging respiratory viruses |
| title | An Update on RNA Virus Discovery: Current Challenges and Future Perspectives |
| title_full | An Update on RNA Virus Discovery: Current Challenges and Future Perspectives |
| title_fullStr | An Update on RNA Virus Discovery: Current Challenges and Future Perspectives |
| title_full_unstemmed | An Update on RNA Virus Discovery: Current Challenges and Future Perspectives |
| title_short | An Update on RNA Virus Discovery: Current Challenges and Future Perspectives |
| title_sort | update on rna virus discovery current challenges and future perspectives |
| topic | RNA virus discovery viral evolution metagenomics zoonotic spillover virus surveillance emerging respiratory viruses |
| url | https://www.mdpi.com/1999-4915/17/7/983 |
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