Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep
<b>Aim:</b> The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses.<p> <b>Materials and Methods:</b> Twenty healthy Akkaraman sheep were enrolled. The a...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2020-10-01
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1293 |
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| Summary: | <b>Aim:</b> The aim of this study was to determine the effects of carprofen
on hematological and biochemical parameters following repeated
intravenous administration of different doses.<p>
<b>Materials and Methods:</b> Twenty healthy Akkaraman sheep were
enrolled. The animals were randomly divided into two equal groups.
Carprofen was administered intravenously to the sheep in the first
group at a dose of 4 mg/kg, and to the sheep in the second group at a
dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram
and biochemical panel blood samples were taken before carprofen
administration (0 hours) and 12, 24, 48, and 120 hours after administration.<p>
<b>Results: </b>There was no difference between hematological and biochemical
parameters of different dose administration groups. The
highest potassium, blood urea nitrogen, aspartate amino transferase
and total protein levels were determined at the 12th hour after administration
of 4 mg/kg carprofen. The highest troponin-I level was
seen at the 12th hour after administration of 16 mg/kg carprofen.
However, the decrease in the levels of red blood cells, hemoglobin
and hematocrit at a dose of 16 mg/kg was more marked, this change
was within the normal reference values.<p>
<b>Conclusion: </b>It has been observed that carprofen can be used safely
at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However,
safety needs to confirm by histopathological and molecular studies. |
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| ISSN: | 1309-6958 2146-1953 |