Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form
New simple, sensitive, rapid, reproducible and economical spectrophotometric method have been developed for the determination of amoxicillin trihydrate in pharmaceutical bulk and tablet dosage form using citro phosphate buffer pH 7.2. The system obeys Lambert-Beer's law at 231 nm in the concent...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/350646 |
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| author | K. Prakash P. Narayana Raju K. Shanta Kumari M. Lakshmi Narasu |
| author_facet | K. Prakash P. Narayana Raju K. Shanta Kumari M. Lakshmi Narasu |
| author_sort | K. Prakash |
| collection | DOAJ |
| description | New simple, sensitive, rapid, reproducible and economical spectrophotometric method have been developed for the determination of amoxicillin trihydrate in pharmaceutical bulk and tablet dosage form using citro phosphate buffer pH 7.2. The system obeys Lambert-Beer's law at 231 nm in the concentration range 2.5-50 μg/m. Molar absorptivity, correlation coefficient and Sandell's sensitivity values were found to be 1.0020 x 104 mol-1 cm, -1 0.9996 and 0.03906 μg cm-2 respectively. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate |
| format | Article |
| id | doaj-art-ec91cc3d8cf745d78691efa22e1ece58 |
| institution | DOAJ |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-ec91cc3d8cf745d78691efa22e1ece582025-08-20T03:21:23ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015S21114111610.1155/2008/350646Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage FormK. Prakash0P. Narayana Raju1K. Shanta Kumari2M. Lakshmi Narasu3SN Vanitha Mahavidyalaya Pharmacy College for Women, Nampally, Hyderabad, Andhra Pradesh, IndiaSt Peter's Institute of Pharmaceutical sciences, Hanmakond, Warangal. Andhra Pradesh, IndiaSN Vanitha Mahavidyalaya Pharmacy College for Women, Nampally, Hyderabad, Andhra Pradesh, IndiaCentre for Biotechnology, Institute of Science and Technology, JNTU, Kukatpally, Hyderabad, IndiaNew simple, sensitive, rapid, reproducible and economical spectrophotometric method have been developed for the determination of amoxicillin trihydrate in pharmaceutical bulk and tablet dosage form using citro phosphate buffer pH 7.2. The system obeys Lambert-Beer's law at 231 nm in the concentration range 2.5-50 μg/m. Molar absorptivity, correlation coefficient and Sandell's sensitivity values were found to be 1.0020 x 104 mol-1 cm, -1 0.9996 and 0.03906 μg cm-2 respectively. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accuratehttp://dx.doi.org/10.1155/2008/350646 |
| spellingShingle | K. Prakash P. Narayana Raju K. Shanta Kumari M. Lakshmi Narasu Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form E-Journal of Chemistry |
| title | Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form |
| title_full | Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form |
| title_fullStr | Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form |
| title_full_unstemmed | Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form |
| title_short | Spectrophotometric Estimation of Amoxicillin Trihydrate in Bulk and Pharmaceutical Dosage Form |
| title_sort | spectrophotometric estimation of amoxicillin trihydrate in bulk and pharmaceutical dosage form |
| url | http://dx.doi.org/10.1155/2008/350646 |
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