Vitamin D and Its Relationship with Obesity and Muscle
The skin synthesis of vitamin D represents the first step of a metabolic pathway whose features have been extensively studied and clarified in the last decades. In particular, the production of active and inactive forms of the hormone and the actions of the corresponding enzymes have offered new ins...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/841248 |
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| _version_ | 1849690049513259008 |
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| author | Cristiana Cipriani Jessica Pepe Sara Piemonte Luciano Colangelo Mirella Cilli Salvatore Minisola |
| author_facet | Cristiana Cipriani Jessica Pepe Sara Piemonte Luciano Colangelo Mirella Cilli Salvatore Minisola |
| author_sort | Cristiana Cipriani |
| collection | DOAJ |
| description | The skin synthesis of vitamin D represents the first step of a metabolic pathway whose features have been extensively studied and clarified in the last decades. In particular, the production of active and inactive forms of the hormone and the actions of the corresponding enzymes have offered new insights into the knowledge of vitamin D metabolism. Additionally, the description of the different organs and tissues expressing the vitamin D receptor and its possible functions, as well as its genetic determinants, have allowed focusing on the interrelationship between vitamin D and many physiological and pathological functions. In this context, many studies reported the association between vitamin D and adipose tissue metabolism, as well as the possible role of the hormone in obesity, weight, and fat mass distribution. Finally, many reports focused on the vitamin D-related effects on skeletal muscle, particularly on the mechanisms by which vitamin D could directly affect muscle mass and strength. This paper is mainly aimed to review vitamin D metabolism and its relationship with obesity and skeletal muscle function. |
| format | Article |
| id | doaj-art-ec88edcc7040408fa335570b1ee62dd7 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ec88edcc7040408fa335570b1ee62dd72025-08-20T03:21:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/841248841248Vitamin D and Its Relationship with Obesity and MuscleCristiana Cipriani0Jessica Pepe1Sara Piemonte2Luciano Colangelo3Mirella Cilli4Salvatore Minisola5Department of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Disciplines, “Sapienza” University, Viale del Policlinico 155, 00161 Rome, ItalyThe skin synthesis of vitamin D represents the first step of a metabolic pathway whose features have been extensively studied and clarified in the last decades. In particular, the production of active and inactive forms of the hormone and the actions of the corresponding enzymes have offered new insights into the knowledge of vitamin D metabolism. Additionally, the description of the different organs and tissues expressing the vitamin D receptor and its possible functions, as well as its genetic determinants, have allowed focusing on the interrelationship between vitamin D and many physiological and pathological functions. In this context, many studies reported the association between vitamin D and adipose tissue metabolism, as well as the possible role of the hormone in obesity, weight, and fat mass distribution. Finally, many reports focused on the vitamin D-related effects on skeletal muscle, particularly on the mechanisms by which vitamin D could directly affect muscle mass and strength. This paper is mainly aimed to review vitamin D metabolism and its relationship with obesity and skeletal muscle function.http://dx.doi.org/10.1155/2014/841248 |
| spellingShingle | Cristiana Cipriani Jessica Pepe Sara Piemonte Luciano Colangelo Mirella Cilli Salvatore Minisola Vitamin D and Its Relationship with Obesity and Muscle International Journal of Endocrinology |
| title | Vitamin D and Its Relationship with Obesity and Muscle |
| title_full | Vitamin D and Its Relationship with Obesity and Muscle |
| title_fullStr | Vitamin D and Its Relationship with Obesity and Muscle |
| title_full_unstemmed | Vitamin D and Its Relationship with Obesity and Muscle |
| title_short | Vitamin D and Its Relationship with Obesity and Muscle |
| title_sort | vitamin d and its relationship with obesity and muscle |
| url | http://dx.doi.org/10.1155/2014/841248 |
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