Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention
Intrahepatic abscess is an exceedingly rare complication of locoregional therapy for patients with liver cancer. However, in patients who underwent prior hepatobiliary intervention, the incidence of liver abscess increases significantly, causing morbidity and even mortality in such patients. Here, w...
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/3/333 |
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| author | Peter Rudnick Kaleb Feia Paul Laeseke Joseph Herman Jeff Geschwind |
| author_facet | Peter Rudnick Kaleb Feia Paul Laeseke Joseph Herman Jeff Geschwind |
| author_sort | Peter Rudnick |
| collection | DOAJ |
| description | Intrahepatic abscess is an exceedingly rare complication of locoregional therapy for patients with liver cancer. However, in patients who underwent prior hepatobiliary intervention, the incidence of liver abscess increases significantly, causing morbidity and even mortality in such patients. Here, we will review the relative risk of developing a liver abscess after intraarterial and ablative locoregional therapies in patients with liver cancer depending on whether they underwent any kind of prior hepatobiliary procedures that resulted in violation of the Ampulla of Vater. As a result, patients deemed at high risk of developing a liver abscess were treated prophylactically, with the combination of bowel preparation and antibiotics nearly eliminating the occurrence of a liver abscess after locoregional therapy. Therefore, given the significant risk of developing a liver abscess in patients with prior hepatobiliary procedures, management consisting of prophylactic bowel preparation with antibiotic coverage followed by antibiotics post-locoregional therapy is recommended. |
| format | Article |
| id | doaj-art-ec88dc2492ea4f08bbc5bdd07794cbc5 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-ec88dc2492ea4f08bbc5bdd07794cbc52025-08-20T02:12:38ZengMDPI AGDiagnostics2075-44182025-01-0115333310.3390/diagnostics15030333Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary InterventionPeter Rudnick0Kaleb Feia1Paul Laeseke2Joseph Herman3Jeff Geschwind4School of Medicine, Creighton University, Omaha, NE 68178, USADepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USADepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USADepartment of Radiation Oncology, Northwell Health, New York, NY 11042, USADivision of Oncology, USA Oncology Centers, Northbrook, IL 60062, USAIntrahepatic abscess is an exceedingly rare complication of locoregional therapy for patients with liver cancer. However, in patients who underwent prior hepatobiliary intervention, the incidence of liver abscess increases significantly, causing morbidity and even mortality in such patients. Here, we will review the relative risk of developing a liver abscess after intraarterial and ablative locoregional therapies in patients with liver cancer depending on whether they underwent any kind of prior hepatobiliary procedures that resulted in violation of the Ampulla of Vater. As a result, patients deemed at high risk of developing a liver abscess were treated prophylactically, with the combination of bowel preparation and antibiotics nearly eliminating the occurrence of a liver abscess after locoregional therapy. Therefore, given the significant risk of developing a liver abscess in patients with prior hepatobiliary procedures, management consisting of prophylactic bowel preparation with antibiotic coverage followed by antibiotics post-locoregional therapy is recommended.https://www.mdpi.com/2075-4418/15/3/333hepatic abscessbilioenteric anastomosisbiliary stentantibiotic prophylaxisbowel preparationintraarterial therapy |
| spellingShingle | Peter Rudnick Kaleb Feia Paul Laeseke Joseph Herman Jeff Geschwind Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention Diagnostics hepatic abscess bilioenteric anastomosis biliary stent antibiotic prophylaxis bowel preparation intraarterial therapy |
| title | Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention |
| title_full | Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention |
| title_fullStr | Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention |
| title_full_unstemmed | Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention |
| title_short | Risk Reduction of Intrahepatic Abscess After Locoregional Therapy for Liver Cancer in Patients with Prior Hepatobiliary Intervention |
| title_sort | risk reduction of intrahepatic abscess after locoregional therapy for liver cancer in patients with prior hepatobiliary intervention |
| topic | hepatic abscess bilioenteric anastomosis biliary stent antibiotic prophylaxis bowel preparation intraarterial therapy |
| url | https://www.mdpi.com/2075-4418/15/3/333 |
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