Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons

Abstract This study aims to determine if neurons derived from induced pluripotent stem cells (iPSCsNs) and directly converted neurons (iNs) from the same source cells exhibit changes in mitochondrial properties related to aging. This research addresses the uncertainty around whether aged iPSCsNs ret...

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Bibliographic Details
Main Authors: Nimmy Varghese, Leonora Szabo, M. Zameel Cader, Imane Lejri, Amandine Grimm, Anne Eckert
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08152-2
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