#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1
Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. T...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/472373 |
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| _version_ | 1850165086135517184 |
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| author | Dalya Al-Saad Misal Giuseppe Memeo Paolo Quadrelli |
| author_facet | Dalya Al-Saad Misal Giuseppe Memeo Paolo Quadrelli |
| author_sort | Dalya Al-Saad |
| collection | DOAJ |
| description | Influenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1. |
| format | Article |
| id | doaj-art-ec83b3e50d8d4476a8ea892e289edfc0 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ec83b3e50d8d4476a8ea892e289edfc02025-08-20T02:21:49ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/472373472373#Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1Dalya Al-Saad0Misal Giuseppe Memeo1Paolo Quadrelli2Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyInfluenza virus flu A H1N1 still remains a target for its inhibition with small molecules. Fleeting nitrosocarbonyl intermediates are at work in a short-cut synthesis of carbocyclic nucleoside analogues. The strategy of the synthetic approaches is presented along with the in vitro antiviral tests. The nucleoside derivatives were tested for their inhibitory activity against a variety of viruses. Promising antiviral activities were found for specific compounds in the case of flu A H1N1.http://dx.doi.org/10.1155/2014/472373 |
| spellingShingle | Dalya Al-Saad Misal Giuseppe Memeo Paolo Quadrelli #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 The Scientific World Journal |
| title | #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 |
| title_full | #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 |
| title_fullStr | #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 |
| title_full_unstemmed | #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 |
| title_short | #Nitrosocarbonyls 1: Antiviral Activity of N-(4-Hydroxycyclohex-2-en-1-yl)quinoline-2-carboxamide against the Influenza A Virus H1N1 |
| title_sort | nitrosocarbonyls 1 antiviral activity of n 4 hydroxycyclohex 2 en 1 yl quinoline 2 carboxamide against the influenza a virus h1n1 |
| url | http://dx.doi.org/10.1155/2014/472373 |
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