Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice.

Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice.

<h4>Background</h4>There is experimental evidence that lethal ischemia-reperfusion injury (IRI) is largely due to mitochondrial permeability transition pore (mPTP) opening, which can be prevented by cyclosporine A (CsA). The aim of our study is to show that a higher dose of CsA (10 mg/kg...

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Bibliographic Details
Main Authors: Sandrine Lemoine, Bruno Pillot, Lionel Augeul, Maud Rabeyrin, Annie Varennes, Gabrielle Normand, Delphine Baetz, Michel Ovize, Laurent Juillard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0182358
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