Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IDD) is a primary cause of low back pain and, in severe cases, can lead to disability. Current treatments for low back pain remain limited in efficacy, underscoring the need for a deeper understanding of the molecular mechanisms driving IDD. The...

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Bibliographic Details
Main Authors:	Yili Xu, Zuozhi Xie, Shubo Gu, Xiang Zhao, Di Zhao, Zhengzheng Wu, Jinfeng Wang, Tao Xu, Ruxue Xu, Zhenhua Feng, Yong Qiu, Zezhang Zhu, Yang Yu, Bo Shi, Jun Jiang
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	Journal of Translational Medicine
Subjects:	Nucleus pulposus Intervertebral disc degeneration Senescence Single-cell sequencing Label-free quantitative proteomics
Online Access:	https://doi.org/10.1186/s12967-025-06798-4
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Fibro-NPC: a pathogenic subtype identified at single-cell resolution with secreted SFRP4 as a biomarker in intervertebral disc degeneration

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