Esketamine mitigates endotoxin-induced acute lung injury by suppressing caspase-11-driven pyroptosis

Esketamine mitigates endotoxin-induced acute lung injury by suppressing caspase-11-driven pyroptosis

Abstract Background Acute lung injury (ALI) is a common complication of endotoxemia, which carries a high risk of morbidity and mortality. Currently, no effective drugs exist to treat endotoxin-induced ALI. This study evaluated esketamine’s protective effects against endotoxin-induced ALI and explor...

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Bibliographic Details
Main Authors: Yunfei Bao, Zhihao Feng, Yanyan Niu, Qing Hu, Haijie Liu, Hongbo Zhang, Jianling Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Anesthesiology
Subjects:
Acute lung injury
Esketamine
Pyroptosis
PI3K/AKT pathway
Caspase-11
Online Access:https://doi.org/10.1186/s12871-025-03220-w
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