Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance

Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance

Abstract Tigecycline is a last-resort antibiotic to treat complicated infections caused by multidrug-resistant pathogens, while the emergence of plasmid-mediated tet(X) family severely compromises its clinical efficacy. Novel antimicrobial strategies not limited to new antibiotics in pharmaceutical...

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Bibliographic Details
Main Authors: Dan Fang, Tianqi Xu, Fulei Li, Yue Sun, Jingyi Sun, Yanqing Yin, Haijie Zhang, Zhiqiang Wang, Yuan Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55791-w
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