Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes
Summary: Although control of movement involves many cortical association areas, bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and deliver feedback information to the primary somatosensory cortex (S1). Compared to the S1, the parietal and premoto...
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Elsevier
2025-05-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725004358 |
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| author | Brandon M. Ruszala Marc H. Schieber |
| author_facet | Brandon M. Ruszala Marc H. Schieber |
| author_sort | Brandon M. Ruszala |
| collection | DOAJ |
| description | Summary: Although control of movement involves many cortical association areas, bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and deliver feedback information to the primary somatosensory cortex (S1). Compared to the S1, the parietal and premotor areas encode more complex information about object properties, hand pre-shaping, and reach trajectories. BMIs therefore might deliver richer information to those cortical association areas than to primary areas. Here, we investigated whether instructions for a center-out task could be delivered via intracortical microstimulation (ICMS) in the anterior intraparietal area (AIP), dorsal posterior parietal cortex (dPPC), or dorsal premotor cortex (PMd) as well as the ventral premotor cortex (PMv) and S1. Two monkeys successfully learned to use AIP, PMv, or S1-ICMS instructions, but neither learned to use dPPC- or PMd-ICMS instructions. The AIP, PMv, and S1 may thus be effective cortical territory for delivering information to the brain, whereas the dPPC or PMd may be comparatively ineffective. |
| format | Article |
| id | doaj-art-ec78b626c8524f249c8e2faad0d9df2d |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-ec78b626c8524f249c8e2faad0d9df2d2025-08-20T02:33:15ZengElsevierCell Reports2211-12472025-05-0144511566410.1016/j.celrep.2025.115664Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodesBrandon M. Ruszala0Marc H. Schieber1Department of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Corresponding authorDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA; Department of Neurology, University of Rochester, Rochester, NY 14642, USA; Department of Neuroscience, University of Rochester, Rochester, NY 14642, USA; Corresponding authorSummary: Although control of movement involves many cortical association areas, bidirectional brain-machine interfaces (BMIs) typically decode movement intent from the motor cortex and deliver feedback information to the primary somatosensory cortex (S1). Compared to the S1, the parietal and premotor areas encode more complex information about object properties, hand pre-shaping, and reach trajectories. BMIs therefore might deliver richer information to those cortical association areas than to primary areas. Here, we investigated whether instructions for a center-out task could be delivered via intracortical microstimulation (ICMS) in the anterior intraparietal area (AIP), dorsal posterior parietal cortex (dPPC), or dorsal premotor cortex (PMd) as well as the ventral premotor cortex (PMv) and S1. Two monkeys successfully learned to use AIP, PMv, or S1-ICMS instructions, but neither learned to use dPPC- or PMd-ICMS instructions. The AIP, PMv, and S1 may thus be effective cortical territory for delivering information to the brain, whereas the dPPC or PMd may be comparatively ineffective.http://www.sciencedirect.com/science/article/pii/S2211124725004358CP: Neuroscience |
| spellingShingle | Brandon M. Ruszala Marc H. Schieber Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes Cell Reports CP: Neuroscience |
| title | Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes |
| title_full | Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes |
| title_fullStr | Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes |
| title_full_unstemmed | Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes |
| title_short | Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes |
| title_sort | injecting information in the cortical reach to grasp network is effective in ventral but not dorsal nodes |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725004358 |
| work_keys_str_mv | AT brandonmruszala injectinginformationinthecorticalreachtograspnetworkiseffectiveinventralbutnotdorsalnodes AT marchschieber injectinginformationinthecorticalreachtograspnetworkiseffectiveinventralbutnotdorsalnodes |