Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment
Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been repor...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05979-x |
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| author | Baile Zuo Xiaoyan Li Dawei Xu Liping Zhao Yang Yang Yi Luan Bi Zhang |
| author_facet | Baile Zuo Xiaoyan Li Dawei Xu Liping Zhao Yang Yang Yi Luan Bi Zhang |
| author_sort | Baile Zuo |
| collection | DOAJ |
| description | Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity. This review offers a comprehensive examination of the relevance of mitochondrial transfer to cardiovascular health and disease, emphasizing the critical functions of mitochondria in energy metabolism and signal transduction within the cardiovascular system. This highlights how disruptions in mitochondrial transfer contribute to various CVDs, such as myocardial infarction, cardiomyopathies, and hypertension. Additionally, we provide an overview of the molecular mechanisms governing mitochondrial transfer and its potential implications for CVD treatment. This finding underscores the therapeutic potential of mitochondrial transfer and addresses the various mechanisms and challenges in its implementation. By delving into mitochondrial transfer and its targeted modulation, this review aims to advance our understanding of cardiovascular disease treatment, presenting new insights and potential therapeutic strategies in this evolving field. |
| format | Article |
| id | doaj-art-ec777d3107244214bc5783ddc3b11b2f |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-ec777d3107244214bc5783ddc3b11b2f2025-01-05T12:44:22ZengBMCJournal of Translational Medicine1479-58762024-12-0122112410.1186/s12967-024-05979-xTargeting mitochondrial transfer: a new horizon in cardiovascular disease treatmentBaile Zuo0Xiaoyan Li1Dawei Xu2Liping Zhao3Yang Yang4Yi Luan5Bi Zhang6Molecular Immunology and Immunotherapy Laboratory, School of Medical Technology, Xinxiang Medical UniversityDepartment of Blood Transfusion, Shanxi Provincial People’s HospitalDepartment of Blood Transfusion, Shanxi Provincial People’s HospitalDepartment of Pathology, Shanxi Provincial People’s HospitalClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou UniversityClinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Blood Transfusion, Shanxi Provincial People’s HospitalAbstract Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity. This review offers a comprehensive examination of the relevance of mitochondrial transfer to cardiovascular health and disease, emphasizing the critical functions of mitochondria in energy metabolism and signal transduction within the cardiovascular system. This highlights how disruptions in mitochondrial transfer contribute to various CVDs, such as myocardial infarction, cardiomyopathies, and hypertension. Additionally, we provide an overview of the molecular mechanisms governing mitochondrial transfer and its potential implications for CVD treatment. This finding underscores the therapeutic potential of mitochondrial transfer and addresses the various mechanisms and challenges in its implementation. By delving into mitochondrial transfer and its targeted modulation, this review aims to advance our understanding of cardiovascular disease treatment, presenting new insights and potential therapeutic strategies in this evolving field.https://doi.org/10.1186/s12967-024-05979-xCardiovascular diseasesMitochondrial transferMyocardial infarctionCardiomyopathiesTherapeutic strategies |
| spellingShingle | Baile Zuo Xiaoyan Li Dawei Xu Liping Zhao Yang Yang Yi Luan Bi Zhang Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment Journal of Translational Medicine Cardiovascular diseases Mitochondrial transfer Myocardial infarction Cardiomyopathies Therapeutic strategies |
| title | Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment |
| title_full | Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment |
| title_fullStr | Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment |
| title_full_unstemmed | Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment |
| title_short | Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment |
| title_sort | targeting mitochondrial transfer a new horizon in cardiovascular disease treatment |
| topic | Cardiovascular diseases Mitochondrial transfer Myocardial infarction Cardiomyopathies Therapeutic strategies |
| url | https://doi.org/10.1186/s12967-024-05979-x |
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