Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation
Thyroid cancer is a malignant tumor of the endocrine system. Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer and has a comparatively better prognosis. An autoimmune disease called Hashimoto’s thyroiditis (HT) affects the thyroid and can cause lymphocyte infiltration in th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1512417/full |
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| author | Shengpeng Yao Hong Zhang |
| author_facet | Shengpeng Yao Hong Zhang |
| author_sort | Shengpeng Yao |
| collection | DOAJ |
| description | Thyroid cancer is a malignant tumor of the endocrine system. Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer and has a comparatively better prognosis. An autoimmune disease called Hashimoto’s thyroiditis (HT) affects the thyroid and can cause lymphocyte infiltration in the thyroid tissue as well as hypothyroidism, which is characterized by increased levels of a certain antibody. It is currently assumed that there is a connection between PTC and HT. HT may increase the incidence of PTC and improve its prognosis by regulating gene expression, participating in common signaling pathways, and creating a specific immune microenvironment. In this review, we summarized the relationship between HT and PTC as well as the effects of coexisting HT on PTC and the possible mechanisms, thereby providing new perspectives for future research. |
| format | Article |
| id | doaj-art-ec75e01ae9d8410f81ee8bcf2aa24948 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-ec75e01ae9d8410f81ee8bcf2aa249482025-08-20T03:06:25ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-04-011610.3389/fendo.2025.15124171512417Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlationShengpeng YaoHong ZhangThyroid cancer is a malignant tumor of the endocrine system. Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer and has a comparatively better prognosis. An autoimmune disease called Hashimoto’s thyroiditis (HT) affects the thyroid and can cause lymphocyte infiltration in the thyroid tissue as well as hypothyroidism, which is characterized by increased levels of a certain antibody. It is currently assumed that there is a connection between PTC and HT. HT may increase the incidence of PTC and improve its prognosis by regulating gene expression, participating in common signaling pathways, and creating a specific immune microenvironment. In this review, we summarized the relationship between HT and PTC as well as the effects of coexisting HT on PTC and the possible mechanisms, thereby providing new perspectives for future research.https://www.frontiersin.org/articles/10.3389/fendo.2025.1512417/fullcancerpapillary thyroid carcinomaHashimoto’s thyroiditisautoimmune diseasethyroid |
| spellingShingle | Shengpeng Yao Hong Zhang Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation Frontiers in Endocrinology cancer papillary thyroid carcinoma Hashimoto’s thyroiditis autoimmune disease thyroid |
| title | Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation |
| title_full | Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation |
| title_fullStr | Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation |
| title_full_unstemmed | Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation |
| title_short | Papillary thyroid carcinoma with Hashimoto’s thyroiditis: impact and correlation |
| title_sort | papillary thyroid carcinoma with hashimoto s thyroiditis impact and correlation |
| topic | cancer papillary thyroid carcinoma Hashimoto’s thyroiditis autoimmune disease thyroid |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1512417/full |
| work_keys_str_mv | AT shengpengyao papillarythyroidcarcinomawithhashimotosthyroiditisimpactandcorrelation AT hongzhang papillarythyroidcarcinomawithhashimotosthyroiditisimpactandcorrelation |