Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis
Abstract Background Polycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism co...
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2025-07-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-02008-w |
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| author | Huseyin Demirci Burak Menekse Enes Ucgul Yuksel Onaran Seyit Murat Bayram Erman Cakal |
| author_facet | Huseyin Demirci Burak Menekse Enes Ucgul Yuksel Onaran Seyit Murat Bayram Erman Cakal |
| author_sort | Huseyin Demirci |
| collection | DOAJ |
| description | Abstract Background Polycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism contribute to an increased risk of atherogenesis. Methods Our study was conducted retrospectively on 347 women with PCOS and 132 healthy women who presented at our clinic. The impact of PCOS on the atherogenic plasma index (AIP) was assessed using multivariable linear regression analysis. Results The AIP was significantly greater in women with PCOS than in controls (p-value < 0.001). A marked increase in AIP was observed when the body mass index (BMI) was ≥ 35 kg/m² (p-value < 0.001). AIP was positively correlated with BMI (r = 0.174, p-value = 0.001) and the homeostatic model assessment for insulin resistance (HOMA-IR) score (r = 0.294, p-value < 0.001). In the multivariable linear regression model including all participants, PCOS diagnosis (B = 0.146, 95% CI = 0.082–0.210; p-value < 0.001) and HOMA-IR (B = 0.017, 95% CI = 0.011–0.022; p-value < 0.001) independently predicted higher AIP. These findings identify PCOS and insulin resistance as independent risk factors for increased atherogenicity. Conclusions PCOS diagnosis and HOMA-IR are independent risk factors for increased atherogenicity. The increased atherogenic burden in women with PCOS can be assessed by the AIP. A significant increase in atherogenicity was observed in patients with a BMI of 35 kg/m² or higher. |
| format | Article |
| id | doaj-art-ec748871db3b4828a7b9ffbecd28fcac |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-ec748871db3b4828a7b9ffbecd28fcac2025-08-20T03:46:04ZengBMCBMC Endocrine Disorders1472-68232025-07-012511910.1186/s12902-025-02008-wImpact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysisHuseyin Demirci0Burak Menekse1Enes Ucgul2Yuksel Onaran3Seyit Murat Bayram4Erman Cakal5Ankara Etlik City Hospital, Department of Endocrinology and MetabolismAnkara Etlik City Hospital, Department of Endocrinology and MetabolismAnkara Etlik City Hospital, Department of Endocrinology and MetabolismAnkara Bilkent City Hospital, Department of Obstetrics and GynecologyAnkara Etlik City Hospital, Department of Endocrinology and MetabolismAnkara Etlik City Hospital, Department of Endocrinology and MetabolismAbstract Background Polycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism contribute to an increased risk of atherogenesis. Methods Our study was conducted retrospectively on 347 women with PCOS and 132 healthy women who presented at our clinic. The impact of PCOS on the atherogenic plasma index (AIP) was assessed using multivariable linear regression analysis. Results The AIP was significantly greater in women with PCOS than in controls (p-value < 0.001). A marked increase in AIP was observed when the body mass index (BMI) was ≥ 35 kg/m² (p-value < 0.001). AIP was positively correlated with BMI (r = 0.174, p-value = 0.001) and the homeostatic model assessment for insulin resistance (HOMA-IR) score (r = 0.294, p-value < 0.001). In the multivariable linear regression model including all participants, PCOS diagnosis (B = 0.146, 95% CI = 0.082–0.210; p-value < 0.001) and HOMA-IR (B = 0.017, 95% CI = 0.011–0.022; p-value < 0.001) independently predicted higher AIP. These findings identify PCOS and insulin resistance as independent risk factors for increased atherogenicity. Conclusions PCOS diagnosis and HOMA-IR are independent risk factors for increased atherogenicity. The increased atherogenic burden in women with PCOS can be assessed by the AIP. A significant increase in atherogenicity was observed in patients with a BMI of 35 kg/m² or higher.https://doi.org/10.1186/s12902-025-02008-wAtherosclerosisHyperandrogenismInsulin resistanceObesityPolycystic ovary syndrome |
| spellingShingle | Huseyin Demirci Burak Menekse Enes Ucgul Yuksel Onaran Seyit Murat Bayram Erman Cakal Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis BMC Endocrine Disorders Atherosclerosis Hyperandrogenism Insulin resistance Obesity Polycystic ovary syndrome |
| title | Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis |
| title_full | Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis |
| title_fullStr | Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis |
| title_full_unstemmed | Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis |
| title_short | Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis |
| title_sort | impact of polycystic ovary syndrome on the atherogenic plasma index a retrospective analysis |
| topic | Atherosclerosis Hyperandrogenism Insulin resistance Obesity Polycystic ovary syndrome |
| url | https://doi.org/10.1186/s12902-025-02008-w |
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