Fatty acid desaturase genetic variations in heart failure and cardiovascular disease

Fatty acid desaturase genetic variations in heart failure and cardiovascular disease

Omega (ω)-3 polyunsaturated fatty acids (PUFAs) have gained prominence for their putative cardioprotective functions. However, the data supporting their beneficial effects has been inconsistent. One possible explanation is that there is genetic variability in the fatty acid desaturase (FADS) 1 and 2...

Full description

Saved in:

Bibliographic Details
Main Authors:	David Gittess, Iain Thompson, Dmitry O. Traktuev, Julio D. Duarte, Ellen C. Keeley
Format:	Article
Language:	English
Published:	Elsevier 2025-05-01
Series:	American Heart Journal Plus
Subjects:	Cardiovascular disease Omega-3 fatty acid Fatty acid desaturase Single nucleotide polymorphism Dietary supplements
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666602225000321
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Associations of delta fatty acid desaturase gene polymorphisms with lipid metabolism disorders
by: Oksana Yu. Kytikova, et al.
Published: (2021-12-01)

Fatty acids as potential biomarkers of stearoyl-CoA desaturase inhibition: Variation in healthy subjects and Parkinson's disease patients
by: Pepijn P.N.M. Eijsvogel, et al.
Published: (2025-12-01)

Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease
by: O. Yu. Kytikova, et al.
Published: (2020-05-01)

Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis
by: Zhicong Chen, et al.
Published: (2025-03-01)

Omega-3 Fatty Acids and Health. A Literature Review
by: Damian Machaj, et al.
Published: (2025-05-01)

Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies
by: Susanne Jäger, et al.
Published: (2025-06-01)

Fungal Δ9-fatty acid desaturase: a unique enzyme at the core of lipid metabolism in Aspergillus fumigatus and a promising target for the search for antifungal strategies
by: Jonatas Erick Maimoni Campanella, et al.
Published: (2025-08-01)

Fucoxanthin promotes the chain lengthening reaction of polyunsaturated fatty acids in vivo by enhancing FADS2 enzyme activity
by: Xiaoyue Li, et al.
Published: (2025-06-01)

Association between asthma and polyunsaturated fatty acids intake in Brazilian adolescents: study of cardiovascular risk in adolescents-ERICA
by: Érica Azevedo de Oliveira Costa Jordão, et al.
Published: (2025-07-01)

Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders
by: Melanie Loix, et al.
Published: (2024-11-01)

Omega-3 supplementation and cardiometabolic risk factors in obese/overweight children and adolescents: a GRADE assessed systematic review and meta-analysis
by: Vali Musazadeh, et al.
Published: (2025-07-01)

The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men
by: Harpa Oskarsdottir, et al.
Published: (2025-07-01)

Genetic mechanisms of disorders in the metabolism of polyunsaturated fatty acids in the development of chronic inflammation in bronchial asthma
by: O. Yu. Kytikova, et al.
Published: (2025-07-01)

Genome-wide identification and diversity of FAD2, FAD3 and FAE1 genes in terms of biotechnological importance in Camelina species
by: Rostyslav Y. Blume, et al.
Published: (2024-12-01)

A Study on the Role of Omega Fatty Acids as an Adjuvant Therapy in Treatment of Amblyopia
by: Shipra Sharda
Published: (2019-01-01)

Genome-wide analysis of fatty acid desaturase genes in moso bamboo (Phyllostachys edulis) reveal their important roles in abiotic stresses responses
by: Chun Fu, et al.
Published: (2024-11-01)

Role of omega-3 unsaturated acids in prevention and treatment of different diseases (part 1)
by: E. Yu. Plotnikova, et al.
Published: (2021-06-01)

Role of omega-3 unsaturated acids in prevention and treatment of different diseases (part 2)
by: M. N. Sinkova, et al.
Published: (2021-06-01)

Implications of Fatty Acids for Age-Related Macular Degeneration: Evidence and Recommendations
by: Shivantika Bisen, et al.
Published: (2025-06-01)

INFLUENCE OF THERMAL HEATING ON THE FATTY ACID COMPOSITION OF TURKEY MEAT ENRICHED WITH LINSEED OIL
by: V. V. Gushchin, et al.
Published: (2016-06-01)

Dissecting the Molecular Mechanism of 10-HDA Biosynthesis: Role of Acyl-CoA Delta(11) Desaturase and Transcriptional Regulators in Honeybee Mandibular Glands
by: Yunchang Li, et al.
Published: (2025-05-01)

The role of fatty acids in attention deficit hyperactivity disorder
by: Fatih Gültekin, et al.
Published: (2022-08-01)

Fatty acid composition of eggs enriched with omega –3 fatty acids on the market
by: Vekoslava STIBILJ, et al.
Published: (1999-12-01)

Challenges and risks of using Omega-3 fatty acids in the supportive treatment of depression
by: Joanna Orzechowska, et al.
Published: (2025-03-01)

Critical appraisal of omega-3 fatty acids in attention-deficit/hyperactivity disorder treatment
by: Königs A, et al.
Published: (2016-07-01)

Building a cell-factory in Crithidia fasciculata: a bio-sustainable system to produce high-value polyunsaturated fatty acids
by: Michela Cerone, et al.
Published: (2025-06-01)

A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci
by: Susan Adanna Ihejirika, et al.
Published: (2025-07-01)

Serum fatty acid profiles in systemic lupus erythematosus and patient reported outcomes: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
by: Kristen N. Gilley, et al.
Published: (2024-12-01)

Omega-3 polyunsaturated fatty acids in cardiology
by: N. V. Perova
Published: (2005-08-01)

Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency
by: Delaney Kaper, et al.
Published: (2025-07-01)

In Vitro Digestion of Chia Seed Oil Nanoemulsions
by: Luciana Julio, et al.
Published: (2024-10-01)

Nutraceutical support in the prevention and treatment of cardiovascular diseases
by: E. V. Gracheva, et al.
Published: (2023-07-01)

Generation of Codon-Optimized Fad3 Gene Transgenic Bovine That Produce More n-3 Polyunsaturated Fatty Acids
by: Guanghua Su, et al.
Published: (2025-01-01)

Comparative Analysis of Fatty Acid Profiles in Erythrocyte Membranes in Vegetarians Compared to Omnivores
by: Marta Despotović, et al.
Published: (2024-02-01)

Omega-3 fatty acids and the treatment of depression: a review of scientific evidence
by: Ab Latif Wani, et al.
Published: (2015-09-01)

Candidate genes associated with fatty acid compositions in north American Atlantic salmon (Salmo salar)
by: Barbara L. Langille, et al.
Published: (2024-12-01)

The Effect of Higenamine Supplementation on the Fatty Acid Profiles of Serum Phospholipids
by: Jelena Rasic Ozegovic, et al.
Published: (2024-02-01)

Omega-3 Fatty Acids and Exercise in Obesity Management: Independent and Synergistic Benefits in Metabolism and Knowledge Gaps
by: Viviana Sandoval, et al.
Published: (2025-04-01)

Does Omega‐3 supplementation increase profuse postpartum hemorrhage? A hospital‐based register study
by: Julia Lichtenstein, et al.
Published: (2024-12-01)

The Molecular Cloning and Functional Analysis of the <i>FAD2</i> Gene in <i>Hippophe rhamnoids</i> L.
by: Di Cong, et al.
Published: (2024-11-01)