RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas
Gliomas represent 70% of all central system nervous tumors and are classified according to the degree of malignancy as low- or high-grade. The permanent activation of the EGFR/PI3K/AKT pathway by various genetic or post-translational alterations of EGFR, PI3KCA, and PTEN has been associated with inc...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/12/1655 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849689396713881600 |
|---|---|
| author | Alveiro Erira Fernando Velandia José Penagos Camilo Zubieta Gonzalo Arboleda |
| author_facet | Alveiro Erira Fernando Velandia José Penagos Camilo Zubieta Gonzalo Arboleda |
| author_sort | Alveiro Erira |
| collection | DOAJ |
| description | Gliomas represent 70% of all central system nervous tumors and are classified according to the degree of malignancy as low- or high-grade. The permanent activation of the EGFR/PI3K/AKT pathway by various genetic or post-translational alterations of EGFR, PI3KCA, and PTEN has been associated with increased proliferation and resistance to apoptosis. The present study aimed to analyze the molecular/genetic changes in the EGFR/PI3K/AKT/PTEN pathway between low-grade and high-grade gliomas in a sample of Colombian patients. A total of 30 samples were tested for PI3K and PTEN mutations, EGFR, PI3K, and AKT gene amplification, AKT, PI3K, BAX, Bcl2 expression levels, and phosphorylation of AKT and PTEN, EGFR and/or PI3K gene amplification was found in 50% of low-grade and 45% of high-grade ones. AKT amplification was found in 25% of the low-grade and 13.6% of the high-grade. The expression of PI3K, AKT, Bcl2, and BAX was increased particularly to a high degree. AKT phosphorylation was found in 66% of low-grade and 31.8% of high-grade. Increased phosphorylation of PTEN was found in 77% low-grade and 66% high-grade. Our results indicate that alterations in the EGFR/PI3K/AKT/PTEN pathway could be important in the initiation and malignant progression of this type of tumor. |
| format | Article |
| id | doaj-art-ec6efcc56c384a049bab84f78bc343c0 |
| institution | DOAJ |
| issn | 2076-3425 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-ec6efcc56c384a049bab84f78bc343c02025-08-20T03:21:39ZengMDPI AGBrain Sciences2076-34252021-12-011112165510.3390/brainsci11121655RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade GliomasAlveiro Erira0Fernando Velandia1José Penagos2Camilo Zubieta3Gonzalo Arboleda4Facultad de Odontología, Universidad Cooperativa de Colombia, Bogotá 111311, ColombiaFacultad de Medicina, Universidad del Rosario, Bogotá 111221, ColombiaNeuro Oncología, Instituto Nacional de Cancerología, Bogotá 111321, ColombiaNeuro Oncología, Instituto Nacional de Cancerología, Bogotá 111321, ColombiaFacultad de Medicina, Universidad Nacional de Colombia, Bogotá 111112, ColombiaGliomas represent 70% of all central system nervous tumors and are classified according to the degree of malignancy as low- or high-grade. The permanent activation of the EGFR/PI3K/AKT pathway by various genetic or post-translational alterations of EGFR, PI3KCA, and PTEN has been associated with increased proliferation and resistance to apoptosis. The present study aimed to analyze the molecular/genetic changes in the EGFR/PI3K/AKT/PTEN pathway between low-grade and high-grade gliomas in a sample of Colombian patients. A total of 30 samples were tested for PI3K and PTEN mutations, EGFR, PI3K, and AKT gene amplification, AKT, PI3K, BAX, Bcl2 expression levels, and phosphorylation of AKT and PTEN, EGFR and/or PI3K gene amplification was found in 50% of low-grade and 45% of high-grade ones. AKT amplification was found in 25% of the low-grade and 13.6% of the high-grade. The expression of PI3K, AKT, Bcl2, and BAX was increased particularly to a high degree. AKT phosphorylation was found in 66% of low-grade and 31.8% of high-grade. Increased phosphorylation of PTEN was found in 77% low-grade and 66% high-grade. Our results indicate that alterations in the EGFR/PI3K/AKT/PTEN pathway could be important in the initiation and malignant progression of this type of tumor.https://www.mdpi.com/2076-3425/11/12/1655cancergliomaspathwayproliferationapoptosis |
| spellingShingle | Alveiro Erira Fernando Velandia José Penagos Camilo Zubieta Gonzalo Arboleda RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas Brain Sciences cancer gliomas pathway proliferation apoptosis |
| title | RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas |
| title_full | RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas |
| title_fullStr | RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas |
| title_full_unstemmed | RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas |
| title_short | RETRACTED: Differential Regulation of the EGFR/PI3K/AKT/PTEN Pathway between Low- and High-Grade Gliomas |
| title_sort | retracted differential regulation of the egfr pi3k akt pten pathway between low and high grade gliomas |
| topic | cancer gliomas pathway proliferation apoptosis |
| url | https://www.mdpi.com/2076-3425/11/12/1655 |
| work_keys_str_mv | AT alveiroerira retracteddifferentialregulationoftheegfrpi3kaktptenpathwaybetweenlowandhighgradegliomas AT fernandovelandia retracteddifferentialregulationoftheegfrpi3kaktptenpathwaybetweenlowandhighgradegliomas AT josepenagos retracteddifferentialregulationoftheegfrpi3kaktptenpathwaybetweenlowandhighgradegliomas AT camilozubieta retracteddifferentialregulationoftheegfrpi3kaktptenpathwaybetweenlowandhighgradegliomas AT gonzaloarboleda retracteddifferentialregulationoftheegfrpi3kaktptenpathwaybetweenlowandhighgradegliomas |