Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice
Nanoplastics (NPs) pollution poses serious health risks and worsens various diseases. However, its role in postoperative complications, particularly perioperative neurocognitive disorders (PNDs), remains unclear. While PNDs are common in the elderly and rare in young adults, lifelong and cumulative...
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Elsevier
2025-06-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325006542 |
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| author | Yu Hou Shuai Li Jian Yu Qi Hou Runjia Wang Xueran Xu Xiyuan Xu Zhichao Li Linhui Ma Qidong Liu Yuan Shen Guotao Peng Hui Zheng |
| author_facet | Yu Hou Shuai Li Jian Yu Qi Hou Runjia Wang Xueran Xu Xiyuan Xu Zhichao Li Linhui Ma Qidong Liu Yuan Shen Guotao Peng Hui Zheng |
| author_sort | Yu Hou |
| collection | DOAJ |
| description | Nanoplastics (NPs) pollution poses serious health risks and worsens various diseases. However, its role in postoperative complications, particularly perioperative neurocognitive disorders (PNDs), remains unclear. While PNDs are common in the elderly and rare in young adults, lifelong and cumulative exposure to NPs may increase the susceptibility of young individuals to PNDs. Herein, surgery alone caused no neurobehavioral impairments in young adult male and female mice and exposed to NPs alone exhibited anxiety-like behavior. However, young adult male and female mice exposed to NPs for 30 days, with surgery on day 31, exhibited postoperative cognitive impairment and anxiety-like behavior associated with PNDs, along with motor dysfunction. Vitamin K2 (VK2) pretreatment mitigated the behavioral impairments induced by nanoplastics and surgery (NS) exposure. RNA sequencing and bioinformatics analysis of male mice revealed that NS activated inflammatory and cell death pathways in the hippocampus (HIP), with upregulation of key genes such as Selp, Timp1, and Emp3. In the medial prefrontal cortex (mPFC), NS exposure upregulated pathways associated with neuronal apoptosis, reactive oxygen species (ROS) processes, and cell death, accompanied by dysregulated expression of genes such as Tert, Adam8, Esr2, and Emp3. VK2 pretreatment rescued these molecular alterations by normalizing the expression of key genes. Additionally, VK2 reduced levels of IL-1β, TNF-α, IL-6, ROS and MDA, while attenuating brain cell apoptosis and microglial activation in the HIP and mPFC of male mice. This study demonstrates that NS exposure increases the susceptibility of young adults to PNDs and highlights VK2 as a promising preventive strategy. Moreover, it elucidates critical molecular pathways and genes, providing a solid foundation for future research. |
| format | Article |
| id | doaj-art-ec6a2cc413dc4591817e2a0708fce959 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-ec6a2cc413dc4591817e2a0708fce9592025-08-20T01:52:42ZengElsevierEcotoxicology and Environmental Safety0147-65132025-06-0129811831810.1016/j.ecoenv.2025.118318Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult miceYu Hou0Shuai Li1Jian Yu2Qi Hou3Runjia Wang4Xueran Xu5Xiyuan Xu6Zhichao Li7Linhui Ma8Qidong Liu9Yuan Shen10Guotao Peng11Hui Zheng12Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaCollege of Environmental Science and Engineering, Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaShandong Provincial Hospital Affiliated to Shandong First Medical University, 250021, ChinaCollege of Environmental Science and Engineering, Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaSchool of Medicine, Tongji University, Shanghai 200331, China; Corresponding authors.Shanghai Tongji Hospital, Tongji University, Shanghai 200065, China; Corresponding authors.College of Environmental Science and Engineering, Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, China; Corresponding authors.Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China; Corresponding authors.Nanoplastics (NPs) pollution poses serious health risks and worsens various diseases. However, its role in postoperative complications, particularly perioperative neurocognitive disorders (PNDs), remains unclear. While PNDs are common in the elderly and rare in young adults, lifelong and cumulative exposure to NPs may increase the susceptibility of young individuals to PNDs. Herein, surgery alone caused no neurobehavioral impairments in young adult male and female mice and exposed to NPs alone exhibited anxiety-like behavior. However, young adult male and female mice exposed to NPs for 30 days, with surgery on day 31, exhibited postoperative cognitive impairment and anxiety-like behavior associated with PNDs, along with motor dysfunction. Vitamin K2 (VK2) pretreatment mitigated the behavioral impairments induced by nanoplastics and surgery (NS) exposure. RNA sequencing and bioinformatics analysis of male mice revealed that NS activated inflammatory and cell death pathways in the hippocampus (HIP), with upregulation of key genes such as Selp, Timp1, and Emp3. In the medial prefrontal cortex (mPFC), NS exposure upregulated pathways associated with neuronal apoptosis, reactive oxygen species (ROS) processes, and cell death, accompanied by dysregulated expression of genes such as Tert, Adam8, Esr2, and Emp3. VK2 pretreatment rescued these molecular alterations by normalizing the expression of key genes. Additionally, VK2 reduced levels of IL-1β, TNF-α, IL-6, ROS and MDA, while attenuating brain cell apoptosis and microglial activation in the HIP and mPFC of male mice. This study demonstrates that NS exposure increases the susceptibility of young adults to PNDs and highlights VK2 as a promising preventive strategy. Moreover, it elucidates critical molecular pathways and genes, providing a solid foundation for future research.http://www.sciencedirect.com/science/article/pii/S0147651325006542NanoplasticsPostoperative complicationsPerioperative neurocognitive disordersNeurotoxicityVitamin K2 |
| spellingShingle | Yu Hou Shuai Li Jian Yu Qi Hou Runjia Wang Xueran Xu Xiyuan Xu Zhichao Li Linhui Ma Qidong Liu Yuan Shen Guotao Peng Hui Zheng Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice Ecotoxicology and Environmental Safety Nanoplastics Postoperative complications Perioperative neurocognitive disorders Neurotoxicity Vitamin K2 |
| title | Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice |
| title_full | Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice |
| title_fullStr | Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice |
| title_full_unstemmed | Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice |
| title_short | Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice |
| title_sort | vitamin k2 prevents postoperative cognitive impairments anxiety like behavior and motor dysfunction induced by nanoplastics in young adult mice |
| topic | Nanoplastics Postoperative complications Perioperative neurocognitive disorders Neurotoxicity Vitamin K2 |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325006542 |
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