Pulmonary hypertension in ischemic heart failure: a pilot study
Aim. To evaluate the role of cardiopulmonary system assessment in a group of patients with pulmonary hypertension (PH) associated with ischemic heart failure (HF) with the right ventricular-pulmonary arterial (RV-PA) coupling.Material and methods. Forty stable patients were examined. The patients we...
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«SILICEA-POLIGRAF» LLC
2024-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4018 |
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| author | V. A. Mareyeva A. A. Bogdanova Т. A. Nikiforova A. A. Klimenko |
| author_facet | V. A. Mareyeva A. A. Bogdanova Т. A. Nikiforova A. A. Klimenko |
| author_sort | V. A. Mareyeva |
| collection | DOAJ |
| description | Aim. To evaluate the role of cardiopulmonary system assessment in a group of patients with pulmonary hypertension (PH) associated with ischemic heart failure (HF) with the right ventricular-pulmonary arterial (RV-PA) coupling.Material and methods. Forty stable patients were examined. The patients were divided into 3 groups depending on the left ventricle ejection fraction (LVEF). PH was established by using expert transthoracic echocardiography. RV-PA coupling was calculated by 2 following ways: as tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio and as TAPSE´Pulmonary Artery Aceleration Time (pACT) multiplication.Results. The patients included in the study were mainly men (73,8%), functional class PH II-III (95,2%), stage IIB CHF (62%). The highest values of TAPSE (18,6±3 mm) and RV-PA coupling (0,64±0,42 mm/mm Hg) were found in the patients with preserved LVEF. In the general cohort, high level of NT-proBNP corresponds to reduced values of RVPA coupling (rs=-0,563) and TAPSE (rs=-0,666; p<0,01). The severity of PH directly affects the level of NT-proBNP (p<0,01). As the stage of HF and PH functional class increases, the indicators of PASP, inferior vena cava diameter and NT-proBNP level significantly increase, as well as TAPSE and RV-PA coupling decrease (p<0,05). Different calculating methods of RV-PA coupling has a strong correlation (rs=0,832; p<0,01).Conclusion. The right heart and RV-PA coupling assessment in patients with ischemic HF of origin is of significant value for the early diagnosis of PH and timely clinical decision-making. |
| format | Article |
| id | doaj-art-ec679491160d4cb5b2383cffaff267dc |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-ec679491160d4cb5b2383cffaff267dc2025-08-20T03:35:50Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252024-09-0123810.15829/1728-8800-2024-40183026Pulmonary hypertension in ischemic heart failure: a pilot studyV. A. Mareyeva0A. A. Bogdanova1Т. A. Nikiforova2A. A. Klimenko3Pirogov Russian National Research Medical University; AO European Medical CenterI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityPirogov Russian National Research Medical University; Pirogov City Clinical Hospital №Aim. To evaluate the role of cardiopulmonary system assessment in a group of patients with pulmonary hypertension (PH) associated with ischemic heart failure (HF) with the right ventricular-pulmonary arterial (RV-PA) coupling.Material and methods. Forty stable patients were examined. The patients were divided into 3 groups depending on the left ventricle ejection fraction (LVEF). PH was established by using expert transthoracic echocardiography. RV-PA coupling was calculated by 2 following ways: as tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio and as TAPSE´Pulmonary Artery Aceleration Time (pACT) multiplication.Results. The patients included in the study were mainly men (73,8%), functional class PH II-III (95,2%), stage IIB CHF (62%). The highest values of TAPSE (18,6±3 mm) and RV-PA coupling (0,64±0,42 mm/mm Hg) were found in the patients with preserved LVEF. In the general cohort, high level of NT-proBNP corresponds to reduced values of RVPA coupling (rs=-0,563) and TAPSE (rs=-0,666; p<0,01). The severity of PH directly affects the level of NT-proBNP (p<0,01). As the stage of HF and PH functional class increases, the indicators of PASP, inferior vena cava diameter and NT-proBNP level significantly increase, as well as TAPSE and RV-PA coupling decrease (p<0,05). Different calculating methods of RV-PA coupling has a strong correlation (rs=0,832; p<0,01).Conclusion. The right heart and RV-PA coupling assessment in patients with ischemic HF of origin is of significant value for the early diagnosis of PH and timely clinical decision-making.https://cardiovascular.elpub.ru/jour/article/view/4018pulmonary hypertensionright ventriclepulmonary arteryheart failureright ventricular dysfunctionechocardiography |
| spellingShingle | V. A. Mareyeva A. A. Bogdanova Т. A. Nikiforova A. A. Klimenko Pulmonary hypertension in ischemic heart failure: a pilot study Кардиоваскулярная терапия и профилактика pulmonary hypertension right ventricle pulmonary artery heart failure right ventricular dysfunction echocardiography |
| title | Pulmonary hypertension in ischemic heart failure: a pilot study |
| title_full | Pulmonary hypertension in ischemic heart failure: a pilot study |
| title_fullStr | Pulmonary hypertension in ischemic heart failure: a pilot study |
| title_full_unstemmed | Pulmonary hypertension in ischemic heart failure: a pilot study |
| title_short | Pulmonary hypertension in ischemic heart failure: a pilot study |
| title_sort | pulmonary hypertension in ischemic heart failure a pilot study |
| topic | pulmonary hypertension right ventricle pulmonary artery heart failure right ventricular dysfunction echocardiography |
| url | https://cardiovascular.elpub.ru/jour/article/view/4018 |
| work_keys_str_mv | AT vamareyeva pulmonaryhypertensioninischemicheartfailureapilotstudy AT aabogdanova pulmonaryhypertensioninischemicheartfailureapilotstudy AT tanikiforova pulmonaryhypertensioninischemicheartfailureapilotstudy AT aaklimenko pulmonaryhypertensioninischemicheartfailureapilotstudy |