Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. Apigenin, a flavonoid found in various herbs and plants, has garnered significant attention for its neuroprotective...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459325000095 |
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| author | Ali Mohammadkhanizadeh Mohammad Sheibani Soroush Taherkhani Davood Nourabadi Seyed Mahdi Mohamadi-Zarch Farnaz Nikbakht Yaser Azizi |
| author_facet | Ali Mohammadkhanizadeh Mohammad Sheibani Soroush Taherkhani Davood Nourabadi Seyed Mahdi Mohamadi-Zarch Farnaz Nikbakht Yaser Azizi |
| author_sort | Ali Mohammadkhanizadeh |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. Apigenin, a flavonoid found in various herbs and plants, has garnered significant attention for its neuroprotective properties. This review aims to provide an update on the potential mechanisms by which apigenin exerts its protective effects in neurodegeneration. Apigenin has been shown to possess potent antioxidant activity, which is thought to play a crucial role in its neuroprotective effects. Oxidative stress, resulting from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses, is a hallmark of neurodegenerative diseases. Apigenin has been demonstrated to scavenge ROS, thereby reducing oxidative stress and mitigating the damage to neurons. Inflammation is another key feature of neurodegenerative diseases, and apigenin has been found to possess anti-inflammatory properties. Apigenin has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which are elevated in neurodegenerative diseases. Moreover, apigenin has been demonstrated to suppress the activation of microglia, the resident immune cells in the brain, which are thought to contribute to neuroinflammation. In addition, apigenin has been shown to activate the PI3K/Akt signaling pathway, which is involved in promoting neuronal survival and preventing apoptosis. In this review, we focus on the underlying mechanisms and signaling pathways involved in neurodegenerative disorders, as well as the diverse beneficial effects of apigenin within these pathways. The literature surveyed spans from 1980 to 2024. Also, systematic search was performed in Embase, MEDLINE, Scopus, Web of Science Core Collection, and Google Scholar for relevant references. Our findings highlight the potential mechanisms associated with the neuroprotective effects of apigenin. |
| format | Article |
| id | doaj-art-ec64403a7d4f46fcab5229076a50526c |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-ec64403a7d4f46fcab5229076a50526c2025-02-08T05:01:19ZengElsevierBrain Disorders2666-45932025-03-0117100189Protective effects of apigenin in neurodegeneration: An update on the potential mechanismsAli Mohammadkhanizadeh0Mohammad Sheibani1Soroush Taherkhani2Davood Nourabadi3Seyed Mahdi Mohamadi-Zarch4Farnaz Nikbakht5Yaser Azizi6Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Physiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Co-corresponding author.Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author.Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. Apigenin, a flavonoid found in various herbs and plants, has garnered significant attention for its neuroprotective properties. This review aims to provide an update on the potential mechanisms by which apigenin exerts its protective effects in neurodegeneration. Apigenin has been shown to possess potent antioxidant activity, which is thought to play a crucial role in its neuroprotective effects. Oxidative stress, resulting from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses, is a hallmark of neurodegenerative diseases. Apigenin has been demonstrated to scavenge ROS, thereby reducing oxidative stress and mitigating the damage to neurons. Inflammation is another key feature of neurodegenerative diseases, and apigenin has been found to possess anti-inflammatory properties. Apigenin has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which are elevated in neurodegenerative diseases. Moreover, apigenin has been demonstrated to suppress the activation of microglia, the resident immune cells in the brain, which are thought to contribute to neuroinflammation. In addition, apigenin has been shown to activate the PI3K/Akt signaling pathway, which is involved in promoting neuronal survival and preventing apoptosis. In this review, we focus on the underlying mechanisms and signaling pathways involved in neurodegenerative disorders, as well as the diverse beneficial effects of apigenin within these pathways. The literature surveyed spans from 1980 to 2024. Also, systematic search was performed in Embase, MEDLINE, Scopus, Web of Science Core Collection, and Google Scholar for relevant references. Our findings highlight the potential mechanisms associated with the neuroprotective effects of apigenin.http://www.sciencedirect.com/science/article/pii/S2666459325000095ApigeninOxidative stressInflammationNeurodegenerationCellular signalings |
| spellingShingle | Ali Mohammadkhanizadeh Mohammad Sheibani Soroush Taherkhani Davood Nourabadi Seyed Mahdi Mohamadi-Zarch Farnaz Nikbakht Yaser Azizi Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms Brain Disorders Apigenin Oxidative stress Inflammation Neurodegeneration Cellular signalings |
| title | Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms |
| title_full | Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms |
| title_fullStr | Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms |
| title_full_unstemmed | Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms |
| title_short | Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms |
| title_sort | protective effects of apigenin in neurodegeneration an update on the potential mechanisms |
| topic | Apigenin Oxidative stress Inflammation Neurodegeneration Cellular signalings |
| url | http://www.sciencedirect.com/science/article/pii/S2666459325000095 |
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