Transcriptomic atlas reveals organ-specific disease tolerance in sickle cell mice

Transcriptomic atlas reveals organ-specific disease tolerance in sickle cell mice

Abstract: Sickle cell disease (SCD) is the most common genetic disease in the world and a societal challenge. SCD is characterized by multiorgan injury related to intravascular hemolysis. To understand tissue-specific responses to intravascular hemolysis and exposure to heme, we present a transcript...

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Main Authors: Anne Grunenwald, Julie Peliconi, Julien Lavergne, Margot Revel, Elodie Voilin, Tania Robe-Rybkine, Gilles Crambert, Jordan D. Dimitrov, Olivier Blanc-Brude, Lubka T. Roumenina
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925000448
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