NKX3-2 Induces Ovarian Cancer Cell Migration by HDAC6-Mediated Repositioning of Lysosomes and Inhibition of Autophagy

NKX3-2 Induces Ovarian Cancer Cell Migration by HDAC6-Mediated Repositioning of Lysosomes and Inhibition of Autophagy

Several soluble factors secreted by the stromal cells and cancer cells within the tumor microenvironment facilitate the progression and invasiveness of ovarian cancer. In ovarian cancer cells, lysophosphatidic acid (LPA) modulates the transcriptome profile and promotes cell invasiveness by the downr...

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Bibliographic Details
Main Authors: Alessandra Ferraresi, Ian Ghezzi, Amreen Salwa, Andrea Esposito, Danny N. Dhanasekaran, Ciro Isidoro
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
autophagy
lysosome
BAPX1
HDAC6
lysophosphatidic acid
epithelial to mesenchymal transition
Online Access:https://www.mdpi.com/2073-4409/13/21/1816
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